Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Individuals with obesity and type 2 diabetes (T2D) are typically insulin resistant, exhibiting impaired skeletal muscle glucose uptake. Animal and cell culture experiments have shown that site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 and TBC1D1 is critical for GLUT4 translocation facilitating glucose uptake, but their regulation in human skeletal muscle is not well understood.
Originalsprog | Engelsk |
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Tidsskrift | Nutrition and Diabetes |
Vol/bind | 3 |
Udgave nummer | 74 |
Sider (fra-til) | e74 |
ISSN | 2044-4052 |
DOI | |
Status | Udgivet - jun. 2013 |
ID: 51255343