Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The human histone demethylases of the KDM4 (JMJD2) family have been associated to diseases such as prostate and breast cancer, as well as X-linked mental retardation. Therefore, these enzymes are considered oncogenes and their selective inhibition might be a possible therapeutic approach to treat cancer. Here we describe a heterocyclic ring system library screened against the histone demethylase KDM4C (JMJD2C) in the search for novel inhibitory scaffolds. A 4-hydroxypyrazole scaffold was identified as an inhibitor of KDM4C; this scaffold could be employed in the further development of novel therapeutics, as well as for the elucidation of the biological roles of KDM4C on epigenetic regulation.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Bioorganic & Medicinal Chemistry Letters |
Vol/bind | 22 |
Udgave nummer | 18 |
Sider (fra-til) | 5811-3 |
Antal sider | 3 |
ISSN | 0960-894X |
DOI | |
Status | Udgivet - 15 sep. 2012 |
ID: 45967576