Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.
Originalsprog | Engelsk |
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Tidsskrift | Antimicrobial Agents and Chemotherapy |
Vol/bind | 50 |
Udgave nummer | 8 |
Sider (fra-til) | 2850-2852 |
Antal sider | 3 |
ISSN | 0066-4804 |
DOI | |
Status | Udgivet - aug. 2006 |
ID: 340559406