TY - JOUR

T1 - Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids

T2 - the DiOGenes study

AU - Brahe, Lena Kirchner

AU - Angquist, Lars

AU - Larsen, Lesli Hingstrup

AU - Vimaleswaran, Karani S

AU - Hager, Jörg

AU - Viguerie, Nathalie

AU - Loos, Ruth J F

AU - Handjieva-Darlenska, Teodora

AU - Jebb, Susan A

AU - Hlavaty, Petr

AU - Larsen, Thomas Meinert

AU - Martinez, J Alfredo

AU - Papadaki, Angeliki

AU - Pfeiffer, Andreas F H

AU - van Baak, Marleen A

AU - Sørensen, Thorkild I A

AU - Holst, Claus

AU - Langin, Dominique

AU - Astrup, Arne

AU - Saris, Wim H M

N1 - CURIS 2013 NEXS 083

PY - 2013

Y1 - 2013

N2 - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

AB - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.

U2 - 10.1017/S0007114512006058

DO - 10.1017/S0007114512006058

M3 - Journal article

C2 - 23360819

VL - 110

SP - 790

EP - 796

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 5

ER -