Influence of psychopathology and metabolic parameters on quality of life in patients with first-episode psychosis before and after initial antipsychotic treatment
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Influence of psychopathology and metabolic parameters on quality of life in patients with first-episode psychosis before and after initial antipsychotic treatment. / Dahl, Anne Sofie A.; Sørensen, Victor; Ambrosen, Karen S.; Sørensen, Mikkel E.; Mohr, Grímur H.; Nielsen, Mette; Bojesen, Kirsten B.; Glenthøj, Birte Y.; Hahn, Margaret; Midtgaard, Julie; Ebdrup, Bjørn H.
I: Schizophrenia, Bind 9, Nr. 1, 76, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Influence of psychopathology and metabolic parameters on quality of life in patients with first-episode psychosis before and after initial antipsychotic treatment
AU - Dahl, Anne Sofie A.
AU - Sørensen, Victor
AU - Ambrosen, Karen S.
AU - Sørensen, Mikkel E.
AU - Mohr, Grímur H.
AU - Nielsen, Mette
AU - Bojesen, Kirsten B.
AU - Glenthøj, Birte Y.
AU - Hahn, Margaret
AU - Midtgaard, Julie
AU - Ebdrup, Bjørn H.
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - The impact of psychological and physical health on quality of life (QoL) in patients with early psychosis remain relatively unexplored. We evaluated the predictive value of psychopathological and metabolic parameters on QoL in antipsychotic-naïve patients with first-episode psychosis before and after initial antipsychotic treatment. At baseline, 125 patients underwent assessments of psychopathology, prevalence of metabolic syndrome (MetS), and QoL. After 6 weeks of antipsychotic monotherapy, 89 patients were re-investigated. At baseline, the prevalence of MetS was 19.3% (n = 22). After 6 weeks, body weight (1.3 kg, p < 0.001) and body mass index (0.4 kg/m2, p < 0.001) increased, and four additional patients developed MetS. Multivariate linear regression revealed that positive and negative symptoms, and to some degree waist circumference, were predictors of QoL at both time points. Our findings suggest that in the earliest stages of antipsychotic treatment, metabolic side-effects may be less influential on QoL than psychopathological severity.
AB - The impact of psychological and physical health on quality of life (QoL) in patients with early psychosis remain relatively unexplored. We evaluated the predictive value of psychopathological and metabolic parameters on QoL in antipsychotic-naïve patients with first-episode psychosis before and after initial antipsychotic treatment. At baseline, 125 patients underwent assessments of psychopathology, prevalence of metabolic syndrome (MetS), and QoL. After 6 weeks of antipsychotic monotherapy, 89 patients were re-investigated. At baseline, the prevalence of MetS was 19.3% (n = 22). After 6 weeks, body weight (1.3 kg, p < 0.001) and body mass index (0.4 kg/m2, p < 0.001) increased, and four additional patients developed MetS. Multivariate linear regression revealed that positive and negative symptoms, and to some degree waist circumference, were predictors of QoL at both time points. Our findings suggest that in the earliest stages of antipsychotic treatment, metabolic side-effects may be less influential on QoL than psychopathological severity.
U2 - 10.1038/s41537-023-00402-8
DO - 10.1038/s41537-023-00402-8
M3 - Journal article
C2 - 37935717
AN - SCOPUS:85175997673
VL - 9
JO - Schizophrenia
JF - Schizophrenia
SN - 2334-265X
IS - 1
M1 - 76
ER -
ID: 373871456