TY - JOUR

T1 - Inflammatory biomarkers and cancer

T2 - CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer

AU - Rasmussen, Line Jee Hartmann

AU - Schultz, Martin

AU - Gaardsting, Anne

AU - Ladelund, Steen

AU - Garred, Peter

AU - Iversen, Kasper

AU - Eugen-Olsen, Jesper

AU - Helms, Morten

AU - David, Kim Peter

AU - Kjaer, Andreas

AU - Lebech, Anne-Mette

AU - Kronborg, Gitte

N1 - © 2017 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.

PY - 2017

Y1 - 2017

N2 - In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC. Patients were included from the DOC, Department of Infectious Diseases, Copenhagen University Hospital Hvidovre. Patients were given a final diagnosis based on the combined results from scans, blood work and physical examination. Weight loss, Charlson score and previous cancer were registered on admission, and plasma concentrations of biomarkers were measured. The primary outcome was incident cancer within 1 year. Out of 197 patients included, 39 patients (19.8%) were diagnosed with cancer. Patients with cancer were significantly older and had a higher burden of comorbidities and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C-reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow-up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs investigated nor self-reported weight loss was associated with cancer. In this study, previous cancer, CRP and suPAR were significantly associated with cancer diagnosis in patients with NSSC. Ficolin-1-3, MBL and pentraxin-3 were not associated with cancer.

AB - In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC. Patients were included from the DOC, Department of Infectious Diseases, Copenhagen University Hospital Hvidovre. Patients were given a final diagnosis based on the combined results from scans, blood work and physical examination. Weight loss, Charlson score and previous cancer were registered on admission, and plasma concentrations of biomarkers were measured. The primary outcome was incident cancer within 1 year. Out of 197 patients included, 39 patients (19.8%) were diagnosed with cancer. Patients with cancer were significantly older and had a higher burden of comorbidities and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C-reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow-up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs investigated nor self-reported weight loss was associated with cancer. In this study, previous cancer, CRP and suPAR were significantly associated with cancer diagnosis in patients with NSSC. Ficolin-1-3, MBL and pentraxin-3 were not associated with cancer.

KW - Age Factors

KW - Aged

KW - Biomarkers, Tumor

KW - C-Reactive Protein

KW - Denmark

KW - Female

KW - Humans

KW - Inflammation

KW - Lectins

KW - Male

KW - Mannose-Binding Lectins

KW - Middle Aged

KW - Neoplasms

KW - Receptors, Urokinase Plasminogen Activator

KW - Serum Amyloid P-Component

KW - Sex Characteristics

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/ijc.30732

DO - 10.1002/ijc.30732

M3 - Journal article

C2 - 28393357

VL - 141

SP - 191

EP - 199

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

ER -