Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria
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Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria. / Jakobsen, P H; Morris-Jones, S; Theander, T G; Hviid, L; Hansen, M B; Bendtzen, K; Ridley, R G; Greenwood, B M.
I: Clinical and Experimental Immunology, Bind 96, Nr. 1, 1994, s. 98-103.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria
AU - Jakobsen, P H
AU - Morris-Jones, S
AU - Theander, T G
AU - Hviid, L
AU - Hansen, M B
AU - Bendtzen, K
AU - Ridley, R G
AU - Greenwood, B M
N1 - Keywords: Antigens, CD8; Child, Preschool; Gambia; Humans; Malaria, Falciparum; Protozoan Proteins; Receptors, Interleukin-2; Receptors, Interleukin-4; Receptors, Mitogen; Solubility; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer
PY - 1994
Y1 - 1994
N2 - Plasma samples from children with mild and severe Plasmodium falciparum malaria and from children with unrelated diseases were collected to investigate whether the clinical outcome of infection was associated with plasma factors which reflected the activity of different cells of the immune system. Children with severe P. falciparum malaria had significantly higher plasma levels of soluble IL-2R than children with mild malaria. Plasma levels of IL-2R and levels of parasitaemia were significantly correlated. Neither parasitaemia nor plasma levels of tumour necrosis factor-alpha (TNF-alpha), IL-6, lymphotoxin (LT), interferon-gamma (IFN-gamma), IL-4, soluble IL-4R or soluble CD8 differed significantly between the two groups of children with malaria. High plasma levels of soluble CD8 were associated with failure of lymphocytes to produce IFN-gamma in vitro following stimulation with P. falciparum antigen. We conclude that soluble IL-2R is a useful marker of disease severity independently of the association with levels of parasitaemia, and that functional regulation of different lymphocyte subsets occurs during acute malaria episodes.
AB - Plasma samples from children with mild and severe Plasmodium falciparum malaria and from children with unrelated diseases were collected to investigate whether the clinical outcome of infection was associated with plasma factors which reflected the activity of different cells of the immune system. Children with severe P. falciparum malaria had significantly higher plasma levels of soluble IL-2R than children with mild malaria. Plasma levels of IL-2R and levels of parasitaemia were significantly correlated. Neither parasitaemia nor plasma levels of tumour necrosis factor-alpha (TNF-alpha), IL-6, lymphotoxin (LT), interferon-gamma (IFN-gamma), IL-4, soluble IL-4R or soluble CD8 differed significantly between the two groups of children with malaria. High plasma levels of soluble CD8 were associated with failure of lymphocytes to produce IFN-gamma in vitro following stimulation with P. falciparum antigen. We conclude that soluble IL-2R is a useful marker of disease severity independently of the association with levels of parasitaemia, and that functional regulation of different lymphocyte subsets occurs during acute malaria episodes.
M3 - Journal article
C2 - 8149674
VL - 96
SP - 98
EP - 103
JO - Clinical and Experimental Immunology, Supplement
JF - Clinical and Experimental Immunology, Supplement
SN - 0964-2536
IS - 1
ER -
ID: 6748342