Increased interictal synchronicity of respiratory related brain pulsations in epilepsy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 1,41 MB, PDF-dokument
Respiratory brain pulsations have recently been shown to drive electrophysiological brain activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory brain pulsations have increased variability and amplitude in patients with epilepsy compared to healthy individuals. To determine whether the respiratory drive is altered in epilepsy, we compared respiratory brain pulsation synchronicity between healthy controls and patients. Whole brain fast functional magnetic resonance imaging was performed on 40 medicated patients with focal epilepsy, 20 drug-naïve patients and 102 healthy controls. Cerebrospinal fluid associated respiratory pulsations were used to generate individual whole brain respiratory synchronization maps, which were compared between groups. Finally, we analyzed the seizure frequency effect and diagnostic accuracy of the respiratory synchronization defect in epilepsy. Respiratory brain pulsations related to the verified fourth ventricle pulsations were significantly more synchronous in patients in frontal, periventricular and mid-temporal regions, while the seizure frequency correlated positively with synchronicity. The respiratory brain synchronicity had a good diagnostic accuracy (ROCAUC = 0.75) in discriminating controls from medicated patients. The elevated respiratory brain synchronicity in focal epilepsy suggests altered physiological effect of cerebrospinal fluid pulsations possibly linked to regional brain water dynamics involved with interictal brain physiology.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Cerebral Blood Flow and Metabolism |
Vol/bind | 42 |
Udgave nummer | 10 |
Sider (fra-til) | 1840-1853 |
Antal sider | 14 |
ISSN | 0271-678X |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work was supported by grants from Finnish Academy grants 275352, 314497, 335720 (VKi), Jane and Aatos Erkko Foundation (VKi), KEVO grants from Oulu University Hospital (VKi), Epilepsy Research Foundation (JK), Finnish Cultural Foundation, North Ostrobothnia Regional Fund (JK), Tauno Tönning Foundation (JK, VKo, VR), The University of Oulu Scholarship Foundation (JK, VR), Medical Research Center (MRC) -Oulu (JK, HH, VR), Maire Taponen Foundation sr (JK), Finnish Brain Foundation sr (VKi, JK), Instrumentarium Science Foundation sr (JK), Orion Research Foundation (JK, TT), The Finnish Medical Foundation (JK, TT), DFG cluster BrainLinks-BrainTools EXC-1086 (PL), Pohjois-Suomen Terveydenhuollon tukisäätiö (VKo, HH). Acknowledgements
Publisher Copyright:
© The Author(s) 2022.
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 314450872