Increase of circulating CD4+CD25highFoxp3+ regulatory T cells in patients with metastatic renal cell carcinoma during treatment with dendritic cell vaccination and low-dose interleukin-2
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Regulatory T cells (Treg) play an important role in the maintenance of immune tolerance and may be one of the obstacles of successful tumor immunotherapy. In this study, we analyzed the impact of administration of dendritic cell (DC) vaccination in combination with low-dose interleukin (IL)-2 in patients with metastatic renal cell carcinoma on the frequency of CD4+CD25highFoxp3+ Treg cells in peripheral blood. We found that the treatment increased the frequency of Treg cells more than 7-fold compared with pretreatment levels (P
Originalsprog | Engelsk |
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Tidsskrift | Journal of Immunotherapy |
Vol/bind | 33 |
Udgave nummer | 4 |
Sider (fra-til) | 425-34 |
Antal sider | 10 |
ISSN | 1524-9557 |
DOI | |
Status | Udgivet - 2010 |
ID: 48579805