In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys

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In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys. / Lee, Blaire; Postnov, Dmitry D; Sørensen, Charlotte M; Sosnovtseva, Olga.

I: Scientific Reports, Bind 13, Nr. 1, 21954, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, B, Postnov, DD, Sørensen, CM & Sosnovtseva, O 2023, 'In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys', Scientific Reports, bind 13, nr. 1, 21954. https://doi.org/10.1038/s41598-023-49327-3

APA

Lee, B., Postnov, D. D., Sørensen, C. M., & Sosnovtseva, O. (2023). In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys. Scientific Reports, 13(1), [21954]. https://doi.org/10.1038/s41598-023-49327-3

Vancouver

Lee B, Postnov DD, Sørensen CM, Sosnovtseva O. In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys. Scientific Reports. 2023;13(1). 21954. https://doi.org/10.1038/s41598-023-49327-3

Author

Lee, Blaire ; Postnov, Dmitry D ; Sørensen, Charlotte M ; Sosnovtseva, Olga. / In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys. I: Scientific Reports. 2023 ; Bind 13, Nr. 1.

Bibtex

@article{f6346ec2562640cc828583be78b3e34c,

title = "In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys",

abstract = "The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear.",

author = "Blaire Lee and Postnov, {Dmitry D} and S{\o}rensen, {Charlotte M} and Olga Sosnovtseva",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

doi = "10.1038/s41598-023-49327-3",

language = "English",

volume = "13",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys

AU - Lee, Blaire

AU - Postnov, Dmitry D

AU - Sørensen, Charlotte M

AU - Sosnovtseva, Olga

PY - 2023

Y1 - 2023

N2 - The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear.

AB - The kidney has a sophisticated vascular structure that performs the unique function of filtering blood and managing blood pressure. Tubuloglomerular feedback is an intra-nephron negative feedback mechanism stabilizing single-nephron blood flow, glomerular filtration rate, and tubular flow rate, which is exhibited as self-sustained oscillations in single-nephron blood flow. We report the application of multi-scale laser speckle imaging to monitor global blood flow changes across the kidney surface (low zoom) and local changes in individual microvessels (high zoom) in normotensive and spontaneously hypertensive rats in vivo. We reveal significant differences in the parameters of TGF-mediated hemodynamics and patterns of synchronization. Furthermore, systemic infusion of a glucagon-like-peptide-1 receptor agonist, a potential renoprotective agent, induces vasodilation in both groups but only alters the magnitude of the TGF in Sprague Dawleys, although the underlying mechanisms remain unclear.

U2 - 10.1038/s41598-023-49327-3

DO - 10.1038/s41598-023-49327-3

M3 - Journal article

C2 - 38081921

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 21954

ER -

ID: 375715509