In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
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As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.
Originalsprog | Engelsk |
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Artikelnummer | e01088-17 |
Tidsskrift | Antimicrobial Agents and Chemotherapy |
Vol/bind | 61 |
Udgave nummer | 10 |
Antal sider | 5 |
ISSN | 0066-4804 |
DOI | |
Status | Udgivet - 2017 |
Links
- http://europepmc.org/articles/pmc5610510?pdf=render
Forlagets udgivne version
ID: 184546017