In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We report an improved method for in situ generation of the Ohira-Bestmann reagent. Using the recently reported bench stable imidazole-1-sulfonyl azide as diazotransfer reagent, this new method represents a safe and scalable approach for the transformation of aldehydes into terminal alkynes. Furthermore the method features easier work-up compared to the existing in situ protocol due to increased aqueous solubility of waste products.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Organic Chemistry |
Vol/bind | 79 |
Udgave nummer | 19 |
Sider (fra-til) | 9423-9426 |
Antal sider | 4 |
ISSN | 0022-3263 |
DOI | |
Status | Udgivet - 12 sep. 2014 |
ID: 123663536