Impaired down-regulation of negative emotion in self-referent social situations in bipolar disorder: A pilot study of a novel experimental paradigm
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Impaired down-regulation of negative emotion in self-referent social situations in bipolar disorder : A pilot study of a novel experimental paradigm. / Kjærstad, Hanne L; Vinberg, Maj; Goldin, Philippe R; Køster, Nicolai; Støttrup, Mette Marie D; Knorr, Ulla; Kessing, Lars V; Miskowiak, Kamilla W.
I: Psychiatry Research, Bind 238, 30.04.2016, s. 318-25.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impaired down-regulation of negative emotion in self-referent social situations in bipolar disorder
T2 - A pilot study of a novel experimental paradigm
AU - Kjærstad, Hanne L
AU - Vinberg, Maj
AU - Goldin, Philippe R
AU - Køster, Nicolai
AU - Støttrup, Mette Marie D
AU - Knorr, Ulla
AU - Kessing, Lars V
AU - Miskowiak, Kamilla W
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/4/30
Y1 - 2016/4/30
N2 - Emotion dysregulation is a core feature of bipolar disorder (BD) that persists into periods of remission. Neuroimaging studies show aberrant neural responses during emotion regulation (ER) in patients with BD relative to healthy controls, but behavioural evidence for ER deficits is sparse and conflicting. This study aimed to explore ER in BD using a novel, personally relevant experimental paradigm. Twenty patients with BD and 20 patients with unipolar disorder (UD), in full or partial remission, and 20 healthy controls were given a novel computerised test. Participants were instructed to react naturally or dampen their emotional response to positive and negative social scenarios and associated self-beliefs. They were also given an established experimental task for comparison, involving reappraisal of negative affective picture stimuli, as well as a questionnaire of habitual ER strategies. BD patients showed reduced ability to down-regulate emotional responses in negative, but not positive, social scenarios relative to healthy controls and UD patients. In contrast, there were no between-group differences in the established ER task or in self-reported habitual reappraisal strategies. Findings highlight the novel social scenario paradigm as a sensitive test for detection of ER difficulties in BD.
AB - Emotion dysregulation is a core feature of bipolar disorder (BD) that persists into periods of remission. Neuroimaging studies show aberrant neural responses during emotion regulation (ER) in patients with BD relative to healthy controls, but behavioural evidence for ER deficits is sparse and conflicting. This study aimed to explore ER in BD using a novel, personally relevant experimental paradigm. Twenty patients with BD and 20 patients with unipolar disorder (UD), in full or partial remission, and 20 healthy controls were given a novel computerised test. Participants were instructed to react naturally or dampen their emotional response to positive and negative social scenarios and associated self-beliefs. They were also given an established experimental task for comparison, involving reappraisal of negative affective picture stimuli, as well as a questionnaire of habitual ER strategies. BD patients showed reduced ability to down-regulate emotional responses in negative, but not positive, social scenarios relative to healthy controls and UD patients. In contrast, there were no between-group differences in the established ER task or in self-reported habitual reappraisal strategies. Findings highlight the novel social scenario paradigm as a sensitive test for detection of ER difficulties in BD.
KW - Adult
KW - Affective Symptoms
KW - Bipolar Disorder
KW - Case-Control Studies
KW - Down-Regulation
KW - Emotions
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Pilot Projects
KW - Journal Article
U2 - 10.1016/j.psychres.2016.02.047
DO - 10.1016/j.psychres.2016.02.047
M3 - Journal article
C2 - 27086251
VL - 238
SP - 318
EP - 325
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -
ID: 177495297