Four dogs referred for suspected protein-losing enteropathy based on clinical signs, severe hypoalbuminemia, and hypocholesterolemia, and in 2 dogs, abdominal effusion or peripheral edema, were diagnosed with hypoadrenocorticism. Dogs with hypoadrenocorticism may have features of protein-losing enteropathy, including ascites or peripheral edema, which have not been described in dogs with hypoadrenocorticism.