Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes

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Standard

Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. / Vind, B F; Birk, Jesper Bratz; Vienberg, Sara Gry; Andersen, B; Beck-Nielsen, Henning; Wojtaszewski, Jørgen; Højlund, Kurt.

I: Diabetologia, Bind 55, Nr. 5, 2012, s. 1435-1445.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vind, BF, Birk, JB, Vienberg, SG, Andersen, B, Beck-Nielsen, H, Wojtaszewski, J & Højlund, K 2012, 'Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes', Diabetologia, bind 55, nr. 5, s. 1435-1445. https://doi.org/10.1007/s00125-012-2482-8

APA

Vind, B. F., Birk, J. B., Vienberg, S. G., Andersen, B., Beck-Nielsen, H., Wojtaszewski, J., & Højlund, K. (2012). Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. Diabetologia, 55(5), 1435-1445. https://doi.org/10.1007/s00125-012-2482-8

Vancouver

Vind BF, Birk JB, Vienberg SG, Andersen B, Beck-Nielsen H, Wojtaszewski J o.a. Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. Diabetologia. 2012;55(5):1435-1445. https://doi.org/10.1007/s00125-012-2482-8

Author

Vind, B F ; Birk, Jesper Bratz ; Vienberg, Sara Gry ; Andersen, B ; Beck-Nielsen, Henning ; Wojtaszewski, Jørgen ; Højlund, Kurt. / Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. I: Diabetologia. 2012 ; Bind 55, Nr. 5. s. 1435-1445.

Bibtex

@article{33c87998491445199af0795c3fd4df8e,
title = "Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes",
abstract = "AIMS/HYPOTHESIS: In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation of glycogen synthase (GS) in skeletal muscle. Hyperglycaemia may compensate for these defects, but to what extent it involves improved insulin signalling to glycogen synthesis remains to be clarified. METHODS: Whole-body glucose metabolism was studied in 12 patients with type 2 diabetes, and 10 lean and 10 obese non-diabetic controls by means of indirect calorimetry and tracers during a euglycaemic-hyperinsulinaemic clamp. The diabetic patients underwent a second isoglycaemic-hyperinsulinaemic clamp maintaining fasting hyperglycaemia. Muscle biopsies from m. vastus lateralis were obtained before and after the clamp for examination of GS and relevant insulin signalling components. RESULTS: During euglycaemia, insulin-stimulated glucose disposal, glucose oxidation and non-oxidative glucose metabolism were reduced in the diabetic group compared with both control groups (p¿",
author = "Vind, {B F} and Birk, {Jesper Bratz} and Vienberg, {Sara Gry} and B Andersen and Henning Beck-Nielsen and J{\o}rgen Wojtaszewski and Kurt H{\o}jlund",
note = "CURIS 2012 5200 026",
year = "2012",
doi = "10.1007/s00125-012-2482-8",
language = "English",
volume = "55",
pages = "1435--1445",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes

AU - Vind, B F

AU - Birk, Jesper Bratz

AU - Vienberg, Sara Gry

AU - Andersen, B

AU - Beck-Nielsen, Henning

AU - Wojtaszewski, Jørgen

AU - Højlund, Kurt

N1 - CURIS 2012 5200 026

PY - 2012

Y1 - 2012

N2 - AIMS/HYPOTHESIS: In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation of glycogen synthase (GS) in skeletal muscle. Hyperglycaemia may compensate for these defects, but to what extent it involves improved insulin signalling to glycogen synthesis remains to be clarified. METHODS: Whole-body glucose metabolism was studied in 12 patients with type 2 diabetes, and 10 lean and 10 obese non-diabetic controls by means of indirect calorimetry and tracers during a euglycaemic-hyperinsulinaemic clamp. The diabetic patients underwent a second isoglycaemic-hyperinsulinaemic clamp maintaining fasting hyperglycaemia. Muscle biopsies from m. vastus lateralis were obtained before and after the clamp for examination of GS and relevant insulin signalling components. RESULTS: During euglycaemia, insulin-stimulated glucose disposal, glucose oxidation and non-oxidative glucose metabolism were reduced in the diabetic group compared with both control groups (p¿

AB - AIMS/HYPOTHESIS: In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation of glycogen synthase (GS) in skeletal muscle. Hyperglycaemia may compensate for these defects, but to what extent it involves improved insulin signalling to glycogen synthesis remains to be clarified. METHODS: Whole-body glucose metabolism was studied in 12 patients with type 2 diabetes, and 10 lean and 10 obese non-diabetic controls by means of indirect calorimetry and tracers during a euglycaemic-hyperinsulinaemic clamp. The diabetic patients underwent a second isoglycaemic-hyperinsulinaemic clamp maintaining fasting hyperglycaemia. Muscle biopsies from m. vastus lateralis were obtained before and after the clamp for examination of GS and relevant insulin signalling components. RESULTS: During euglycaemia, insulin-stimulated glucose disposal, glucose oxidation and non-oxidative glucose metabolism were reduced in the diabetic group compared with both control groups (p¿

U2 - 10.1007/s00125-012-2482-8

DO - 10.1007/s00125-012-2482-8

M3 - Journal article

C2 - 22322917

VL - 55

SP - 1435

EP - 1445

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 5

ER -

ID: 37589103