Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival
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Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. / Jensen, David Hebbelstrup; Hedback, Nora; Specht, Lena; Høgdall, Estrid; Andersen, Elo; Therkildsen, Marianne Hamilton; Friis-Hansen, Lennart; Norrild, Bodil; von Buchwald, Christian.
I: PLOS ONE, Bind 9, Nr. 11, e110456, 2014, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival
AU - Jensen, David Hebbelstrup
AU - Hedback, Nora
AU - Specht, Lena
AU - Høgdall, Estrid
AU - Andersen, Elo
AU - Therkildsen, Marianne Hamilton
AU - Friis-Hansen, Lennart
AU - Norrild, Bodil
AU - von Buchwald, Christian
PY - 2014
Y1 - 2014
N2 - BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.
AB - BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP).METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records.RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038-0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis.CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.
U2 - 10.1371/journal.pone.0110456
DO - 10.1371/journal.pone.0110456
M3 - Journal article
C2 - 25369118
VL - 9
SP - 1
EP - 8
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - e110456
ER -
ID: 129816639