Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells
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Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells. / Billestrup, Nils.
I: Biomedica Biochimica Acta, Bind 44, Nr. 1, 1985, s. 85-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells
AU - Billestrup, Nils
PY - 1985
Y1 - 1985
N2 - Binding of 125I labelled human growth hormone to cloned insulin producing RIN-5AH cells is described. Binding was specific for somatotropic hormones since both human and rat growth hormone could compete for binding sites, whereas much higher concentrations of lactogenic hormones were needed to inhibit binding. Culture of RIN-5AH cells in the presence of hGH stimulated insulin biosynthesis by 85%.
AB - Binding of 125I labelled human growth hormone to cloned insulin producing RIN-5AH cells is described. Binding was specific for somatotropic hormones since both human and rat growth hormone could compete for binding sites, whereas much higher concentrations of lactogenic hormones were needed to inhibit binding. Culture of RIN-5AH cells in the presence of hGH stimulated insulin biosynthesis by 85%.
KW - Adenoma, Islet Cell
KW - Animals
KW - Cell Line
KW - Growth Hormone
KW - Insulin
KW - Insulinoma
KW - Rats
KW - Receptors, Cell Surface
KW - Receptors, Somatotropin
M3 - Journal article
C2 - 2986615
VL - 44
SP - 85
EP - 87
JO - Biomedica Biochimica Acta
JF - Biomedica Biochimica Acta
SN - 0232-766X
IS - 1
ER -
ID: 132900962