How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium
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How to RESPOND to Modern Challenges for People Living with HIV : A Profile for a New Cohort Consortium. / The Respond Study Group; Neesgaard, Bastian; Mocroft, Amanda; Greenberg, Lauren; Larsen, Jakob Friis; Kirk, Ole; Podlekareva, Daria; Raben, Dorthe; Peters, Lars; Volny-Anne, Alain; Lundgren, Jens; Ryom, Lene.
I: Microorganisms, Bind 8, 1164, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - How to RESPOND to Modern Challenges for People Living with HIV
T2 - A Profile for a New Cohort Consortium
AU - The Respond Study Group
AU - Neesgaard, Bastian
AU - Mocroft, Amanda
AU - Greenberg, Lauren
AU - Larsen, Jakob Friis
AU - Kirk, Ole
AU - Podlekareva, Daria
AU - Raben, Dorthe
AU - Peters, Lars
AU - Volny-Anne, Alain
AU - Lundgren, Jens
AU - Ryom, Lene
PY - 2020
Y1 - 2020
N2 - BACKGROUND: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases.METHODS: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12.RESULTS: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438-830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events.CONCLUSION: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.
AB - BACKGROUND: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases.METHODS: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12.RESULTS: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438-830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events.CONCLUSION: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.
U2 - 10.3390/microorganisms8081164
DO - 10.3390/microorganisms8081164
M3 - Journal article
C2 - 32752044
VL - 8
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
M1 - 1164
ER -
ID: 255556977