How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

  • The Respond Study Group
  • Bastian Neesgaard
  • Amanda Mocroft
  • Lauren Greenberg
  • Jakob Friis Larsen
  • Kirk, Ole
  • Daria Podlekareva
  • Dorthe Raben
  • Lars Peters
  • Alain Volny-Anne
  • Lundgren, Jens
  • Lene Ryom

BACKGROUND: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases.

METHODS: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12.

RESULTS: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438-830). Malignancies (n = 361) and cardiovascular disease (n = 168) were the predominant reported clinical events.

CONCLUSION: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.

OriginalsprogEngelsk
Artikelnummer1164
TidsskriftMicroorganisms
Vol/bind8
Antal sider16
ISSN2076-2607
DOI
StatusUdgivet - 2020

ID: 255556977