How do inositol phosphates regulate calcium signaling?

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Standard

How do inositol phosphates regulate calcium signaling? / Putney, J W; Takemura, H; Hughes, A R; Horstman, D A; Thastrup, Ole.

I: F A S E B Journal, Bind 3, Nr. 8, 1989, s. 1899-905.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Putney, JW, Takemura, H, Hughes, AR, Horstman, DA & Thastrup, O 1989, 'How do inositol phosphates regulate calcium signaling?', F A S E B Journal, bind 3, nr. 8, s. 1899-905.

APA

Putney, J. W., Takemura, H., Hughes, A. R., Horstman, D. A., & Thastrup, O. (1989). How do inositol phosphates regulate calcium signaling? F A S E B Journal, 3(8), 1899-905.

Vancouver

Putney JW, Takemura H, Hughes AR, Horstman DA, Thastrup O. How do inositol phosphates regulate calcium signaling? F A S E B Journal. 1989;3(8):1899-905.

Author

Putney, J W ; Takemura, H ; Hughes, A R ; Horstman, D A ; Thastrup, Ole. / How do inositol phosphates regulate calcium signaling?. I: F A S E B Journal. 1989 ; Bind 3, Nr. 8. s. 1899-905.

Bibtex

@article{44ed03d9fb064940b672767574a93e26,
title = "How do inositol phosphates regulate calcium signaling?",
abstract = "Activation of a variety of cell surface receptors results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate, with concomitant formation of inositol 1,4,5-trisphosphate and diacylglycerol. There is strong evidence that inositol 1,4,5-trisphosphate stimulates Ca2+ release from intracellular stores. The Ca2+-releasing actions of inositol 1,4,5-trisphosphate are terminated by its metabolism through two distinct pathways. Inositol 1,4,5-trisphosphate is dephosphorylated by a 5-phosphatase to inositol 1,4-bisphosphate; alternatively, inositol 1,4,5-trisphosphate can also be phosphorylated to inositol 1,3,4,5-tetrakisphosphate by a 3-kinase. Although the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known; the proposal that inositol 1,4,5-trisphosphate secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool is considered.",
keywords = "Animals, Calcium, Calcium Channels, Cell Membrane, Humans, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Inositol Phosphates, Phosphorylation, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Sugar Phosphates, Type C Phospholipases",
author = "Putney, {J W} and H Takemura and Hughes, {A R} and Horstman, {D A} and Ole Thastrup",
year = "1989",
language = "English",
volume = "3",
pages = "1899--905",
journal = "F A S E B Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "8",

}

RIS

TY - JOUR

T1 - How do inositol phosphates regulate calcium signaling?

AU - Putney, J W

AU - Takemura, H

AU - Hughes, A R

AU - Horstman, D A

AU - Thastrup, Ole

PY - 1989

Y1 - 1989

N2 - Activation of a variety of cell surface receptors results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate, with concomitant formation of inositol 1,4,5-trisphosphate and diacylglycerol. There is strong evidence that inositol 1,4,5-trisphosphate stimulates Ca2+ release from intracellular stores. The Ca2+-releasing actions of inositol 1,4,5-trisphosphate are terminated by its metabolism through two distinct pathways. Inositol 1,4,5-trisphosphate is dephosphorylated by a 5-phosphatase to inositol 1,4-bisphosphate; alternatively, inositol 1,4,5-trisphosphate can also be phosphorylated to inositol 1,3,4,5-tetrakisphosphate by a 3-kinase. Although the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known; the proposal that inositol 1,4,5-trisphosphate secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool is considered.

AB - Activation of a variety of cell surface receptors results in the phospholipase C-catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate, with concomitant formation of inositol 1,4,5-trisphosphate and diacylglycerol. There is strong evidence that inositol 1,4,5-trisphosphate stimulates Ca2+ release from intracellular stores. The Ca2+-releasing actions of inositol 1,4,5-trisphosphate are terminated by its metabolism through two distinct pathways. Inositol 1,4,5-trisphosphate is dephosphorylated by a 5-phosphatase to inositol 1,4-bisphosphate; alternatively, inositol 1,4,5-trisphosphate can also be phosphorylated to inositol 1,3,4,5-tetrakisphosphate by a 3-kinase. Although the mechanism of Ca2+ mobilization is understood, the precise mechanisms involved in Ca2+ entry are not known; the proposal that inositol 1,4,5-trisphosphate secondarily elicits Ca2+ entry by emptying an intracellular Ca2+ pool is considered.

KW - Animals

KW - Calcium

KW - Calcium Channels

KW - Cell Membrane

KW - Humans

KW - Inositol 1,4,5-Trisphosphate

KW - Inositol 1,4,5-Trisphosphate Receptors

KW - Inositol Phosphates

KW - Phosphorylation

KW - Receptors, Cell Surface

KW - Receptors, Cytoplasmic and Nuclear

KW - Signal Transduction

KW - Sugar Phosphates

KW - Type C Phospholipases

M3 - Journal article

C2 - 2542110

VL - 3

SP - 1899

EP - 1905

JO - F A S E B Journal

JF - F A S E B Journal

SN - 0892-6638

IS - 8

ER -

ID: 43350103