Hippocampal volume changes in healthy subjects at risk of unipolar depression

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Standard

Hippocampal volume changes in healthy subjects at risk of unipolar depression. / Baaré, William F C; Vinberg, Maj; Knudsen, Gitte M; Paulson, Olaf B; Langkilde, Annika R; Jernigan, Terry L; Kessing, Lars Vedel.

I: Journal of Psychiatric Research, Bind 44, Nr. 10, 2010, s. 655-662.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Baaré, WFC, Vinberg, M, Knudsen, GM, Paulson, OB, Langkilde, AR, Jernigan, TL & Kessing, LV 2010, 'Hippocampal volume changes in healthy subjects at risk of unipolar depression', Journal of Psychiatric Research, bind 44, nr. 10, s. 655-662. https://doi.org/10.1016/j.jpsychires.2009.12.009, https://doi.org/10.1016/j.jpsychires.2009.12.009

APA

Baaré, W. F. C., Vinberg, M., Knudsen, G. M., Paulson, O. B., Langkilde, A. R., Jernigan, T. L., & Kessing, L. V. (2010). Hippocampal volume changes in healthy subjects at risk of unipolar depression. Journal of Psychiatric Research, 44(10), 655-662. https://doi.org/10.1016/j.jpsychires.2009.12.009, https://doi.org/10.1016/j.jpsychires.2009.12.009

Vancouver

Baaré WFC, Vinberg M, Knudsen GM, Paulson OB, Langkilde AR, Jernigan TL o.a. Hippocampal volume changes in healthy subjects at risk of unipolar depression. Journal of Psychiatric Research. 2010;44(10):655-662. https://doi.org/10.1016/j.jpsychires.2009.12.009, https://doi.org/10.1016/j.jpsychires.2009.12.009

Author

Baaré, William F C ; Vinberg, Maj ; Knudsen, Gitte M ; Paulson, Olaf B ; Langkilde, Annika R ; Jernigan, Terry L ; Kessing, Lars Vedel. / Hippocampal volume changes in healthy subjects at risk of unipolar depression. I: Journal of Psychiatric Research. 2010 ; Bind 44, Nr. 10. s. 655-662.

Bibtex

@article{60d10c33ba364904a1cb2ea43ca1225e,

title = "Hippocampal volume changes in healthy subjects at risk of unipolar depression",

abstract = "Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p<0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.",

keywords = "Adult, Brain Mapping, Depressive Disorder, Female, Genetic Predisposition to Disease, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Reference Values, Risk Factors, Twins, Dizygotic, Twins, Monozygotic",

author = "Baar{\'e}, {William F C} and Maj Vinberg and Knudsen, {Gitte M} and Paulson, {Olaf B} and Langkilde, {Annika R} and Jernigan, {Terry L} and Kessing, {Lars Vedel}",

year = "2010",

doi = "10.1016/j.jpsychires.2009.12.009",

language = "English",

volume = "44",

pages = "655--662",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Pergamon Press",

number = "10",

}

RIS

TY - JOUR

T1 - Hippocampal volume changes in healthy subjects at risk of unipolar depression

AU - Baaré, William F C

AU - Vinberg, Maj

AU - Knudsen, Gitte M

AU - Paulson, Olaf B

AU - Langkilde, Annika R

AU - Jernigan, Terry L

AU - Kessing, Lars Vedel

PY - 2010

Y1 - 2010

N2 - Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p<0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.

AB - Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p<0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.

KW - Adult

KW - Brain Mapping

KW - Depressive Disorder

KW - Female

KW - Genetic Predisposition to Disease

KW - Hippocampus

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Organ Size

KW - Reference Values

KW - Risk Factors

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1016/j.jpsychires.2009.12.009

DO - 10.1016/j.jpsychires.2009.12.009

M3 - Journal article

C2 - 20096419

VL - 44

SP - 655

EP - 662

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 10

ER -

ID: 33434577