Hippocampal volume changes in healthy subjects at risk of unipolar depression
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Hippocampal volume changes in healthy subjects at risk of unipolar depression. / Baaré, William F C; Vinberg, Maj; Knudsen, Gitte M; Paulson, Olaf B; Langkilde, Annika R; Jernigan, Terry L; Kessing, Lars Vedel.
I: Journal of Psychiatric Research, Bind 44, Nr. 10, 2010, s. 655-662.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Hippocampal volume changes in healthy subjects at risk of unipolar depression
AU - Baaré, William F C
AU - Vinberg, Maj
AU - Knudsen, Gitte M
AU - Paulson, Olaf B
AU - Langkilde, Annika R
AU - Jernigan, Terry L
AU - Kessing, Lars Vedel
N1 - Copyright © 2009 Elsevier Ltd. All rights reserved.
PY - 2010
Y1 - 2010
N2 - Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p<0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.
AB - Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p<0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.
KW - Adult
KW - Brain Mapping
KW - Depressive Disorder
KW - Female
KW - Genetic Predisposition to Disease
KW - Hippocampus
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Organ Size
KW - Reference Values
KW - Risk Factors
KW - Twins, Dizygotic
KW - Twins, Monozygotic
U2 - 10.1016/j.jpsychires.2009.12.009
DO - 10.1016/j.jpsychires.2009.12.009
M3 - Journal article
C2 - 20096419
VL - 44
SP - 655
EP - 662
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
IS - 10
ER -
ID: 33434577