Heterogeneity of secretory granules of silent pituitary adenomas.

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Standard

Heterogeneity of secretory granules of silent pituitary adenomas. / Holck, S; Wewer, U M; Albrechtsen, R.

I: Modern Pathology, Bind 1, Nr. 3, 1988, s. 212-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Holck, S, Wewer, UM & Albrechtsen, R 1988, 'Heterogeneity of secretory granules of silent pituitary adenomas.', Modern Pathology, bind 1, nr. 3, s. 212-5.

APA

Holck, S., Wewer, U. M., & Albrechtsen, R. (1988). Heterogeneity of secretory granules of silent pituitary adenomas. Modern Pathology, 1(3), 212-5.

Vancouver

Holck S, Wewer UM, Albrechtsen R. Heterogeneity of secretory granules of silent pituitary adenomas. Modern Pathology. 1988;1(3):212-5.

Author

Holck, S ; Wewer, U M ; Albrechtsen, R. / Heterogeneity of secretory granules of silent pituitary adenomas. I: Modern Pathology. 1988 ; Bind 1, Nr. 3. s. 212-5.

Bibtex

@article{be6a2e405c7d11dd8d9f000ea68e967b,
title = "Heterogeneity of secretory granules of silent pituitary adenomas.",
abstract = "Silent pituitary adenomas were compared with hormonally active tumors taking into account the size, number, and ultrastructural characteristics of secretory granules (SG). The study group (a total of 79 primary pituitary adenomas) comprised 27 silent, 21 growth hormone (GH)-producing-, 16 prolactin (PRL)-producing-, 5 GH-PRL-producing- and 10 adrenocorticotropic hormone (ACTH)-producing adenomas. The SG of silent adenomas were significantly smaller than SG in endocrine active adenomas. All hormonally inactive tumors also contained small (mean, 94 nm) specific cytoplasmic granules, designated {"}silent adenoma granules{"} (SIG). The fine structural features of the SIG included: a flocculent, granular material occupying an eccentric position in a larger vesicle limited by a double membrane. In the silent adenomas this particular granule was present in up to 90% of the adenoma cells and constituted approximately 10 to 50% of the granules in each cell. These granules were not seen in hormonally active tumors and considered therefore diagnostic of silent pituitary adenomas.",
author = "S Holck and Wewer, {U M} and R Albrechtsen",
note = "Keywords: Adenoma; Cytoplasmic Granules; Humans; Microscopy, Electron; Pituitary Neoplasms",
year = "1988",
language = "English",
volume = "1",
pages = "212--5",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "nature publishing group",
number = "3",

}

RIS

TY - JOUR

T1 - Heterogeneity of secretory granules of silent pituitary adenomas.

AU - Holck, S

AU - Wewer, U M

AU - Albrechtsen, R

N1 - Keywords: Adenoma; Cytoplasmic Granules; Humans; Microscopy, Electron; Pituitary Neoplasms

PY - 1988

Y1 - 1988

N2 - Silent pituitary adenomas were compared with hormonally active tumors taking into account the size, number, and ultrastructural characteristics of secretory granules (SG). The study group (a total of 79 primary pituitary adenomas) comprised 27 silent, 21 growth hormone (GH)-producing-, 16 prolactin (PRL)-producing-, 5 GH-PRL-producing- and 10 adrenocorticotropic hormone (ACTH)-producing adenomas. The SG of silent adenomas were significantly smaller than SG in endocrine active adenomas. All hormonally inactive tumors also contained small (mean, 94 nm) specific cytoplasmic granules, designated "silent adenoma granules" (SIG). The fine structural features of the SIG included: a flocculent, granular material occupying an eccentric position in a larger vesicle limited by a double membrane. In the silent adenomas this particular granule was present in up to 90% of the adenoma cells and constituted approximately 10 to 50% of the granules in each cell. These granules were not seen in hormonally active tumors and considered therefore diagnostic of silent pituitary adenomas.

AB - Silent pituitary adenomas were compared with hormonally active tumors taking into account the size, number, and ultrastructural characteristics of secretory granules (SG). The study group (a total of 79 primary pituitary adenomas) comprised 27 silent, 21 growth hormone (GH)-producing-, 16 prolactin (PRL)-producing-, 5 GH-PRL-producing- and 10 adrenocorticotropic hormone (ACTH)-producing adenomas. The SG of silent adenomas were significantly smaller than SG in endocrine active adenomas. All hormonally inactive tumors also contained small (mean, 94 nm) specific cytoplasmic granules, designated "silent adenoma granules" (SIG). The fine structural features of the SIG included: a flocculent, granular material occupying an eccentric position in a larger vesicle limited by a double membrane. In the silent adenomas this particular granule was present in up to 90% of the adenoma cells and constituted approximately 10 to 50% of the granules in each cell. These granules were not seen in hormonally active tumors and considered therefore diagnostic of silent pituitary adenomas.

M3 - Journal article

C2 - 3237702

VL - 1

SP - 212

EP - 215

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 3

ER -

ID: 5236892