Health-related quality of life in long-term survivors of childhood brain tumors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Health-related quality of life in long-term survivors of childhood brain tumors. / Reimers, Tonny Solveig; Mortensen, Erik Lykke; Nysom, Karsten; Schmiegelow, Kjeld; Reimers, Tonny Solveig; Mortensen, Erik Lykke; Nysom, Karsten; Schmiegelow, Kjeld.

I: Pediatric Blood & Cancer, Bind 53, Nr. 6, 01.12.2009, s. 1086-91.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Reimers, TS, Mortensen, EL, Nysom, K, Schmiegelow, K, Reimers, TS, Mortensen, EL, Nysom, K & Schmiegelow, K 2009, 'Health-related quality of life in long-term survivors of childhood brain tumors', Pediatric Blood & Cancer, bind 53, nr. 6, s. 1086-91. https://doi.org/10.1002/pbc.22122, https://doi.org/10.1002/pbc.22122

APA

Reimers, T. S., Mortensen, E. L., Nysom, K., Schmiegelow, K., Reimers, T. S., Mortensen, E. L., ... Schmiegelow, K. (2009). Health-related quality of life in long-term survivors of childhood brain tumors. Pediatric Blood & Cancer, 53(6), 1086-91. https://doi.org/10.1002/pbc.22122, https://doi.org/10.1002/pbc.22122

Vancouver

Reimers TS, Mortensen EL, Nysom K, Schmiegelow K, Reimers TS, Mortensen EL o.a. Health-related quality of life in long-term survivors of childhood brain tumors. Pediatric Blood & Cancer. 2009 dec 1;53(6):1086-91. https://doi.org/10.1002/pbc.22122, https://doi.org/10.1002/pbc.22122

Author

Reimers, Tonny Solveig ; Mortensen, Erik Lykke ; Nysom, Karsten ; Schmiegelow, Kjeld ; Reimers, Tonny Solveig ; Mortensen, Erik Lykke ; Nysom, Karsten ; Schmiegelow, Kjeld. / Health-related quality of life in long-term survivors of childhood brain tumors. I: Pediatric Blood & Cancer. 2009 ; Bind 53, Nr. 6. s. 1086-91.

Bibtex

@article{8d011640b1b111debc73000ea68e967b,
title = "Health-related quality of life in long-term survivors of childhood brain tumors",
abstract = "BACKGROUND: To identify predictors for health-related quality of life (HRQOL) in survivors of childhood brain tumors and its relationship to cognitive function. PROCEDURE: One hundred twenty-six consecutive Danish childhood brain tumor patients treated 1970-1997 and being 7.9-40.4 years at follow-up were assessed for general intelligence (IQ) and administered the Minneapolis-Manchester Quality of Life (MMQL) questionnaire. RESULTS: In multivariate linear regression treatment with RT was the most important risk factor for reduced HRQOL. Lower scores for physical functioning and energy, social functioning, cognitive functioning, body image, outlook of life, and intimate relations were significantly related to RT. Tumor location in the posterior fossa was associated with lower scores for physical functioning and energy, and tumor site in the third ventricle region was associated with lower scores for body image. Younger age at diagnosis was associated with lower scores for social functioning and intimate relations, and younger age at follow-up was associated with more physical symptoms. When IQ was included as a covariate, RT only remained significant for social functioning and intimate relations while tumor location in the third ventricle region remained significant for body image, younger age at diagnosis for social functioning and intimate relations, and younger age at follow-up for physical symptoms. In contrasts, neither gender nor presence of hydrocephalus requiring shunt inserted predicted significantly reduced HRQOL in the multivariate analyses. CONCLUSION: RT is an important predictor of HRQOL primarily due to its effect on general intelligence, which suggests that IQ is a strong determinant of HRQOL.",
author = "Reimers, {Tonny Solveig} and Mortensen, {Erik Lykke} and Karsten Nysom and Kjeld Schmiegelow and Reimers, {Tonny Solveig} and Mortensen, {Erik Lykke} and Karsten Nysom and Kjeld Schmiegelow",
year = "2009",
month = "12",
day = "1",
doi = "10.1002/pbc.22122",
language = "English",
volume = "53",
pages = "1086--91",
journal = "Pediatric Blood & Cancer",
issn = "1545-5009",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Health-related quality of life in long-term survivors of childhood brain tumors

AU - Reimers, Tonny Solveig

AU - Mortensen, Erik Lykke

AU - Nysom, Karsten

AU - Schmiegelow, Kjeld

AU - Reimers, Tonny Solveig

AU - Mortensen, Erik Lykke

AU - Nysom, Karsten

AU - Schmiegelow, Kjeld

PY - 2009/12/1

Y1 - 2009/12/1

N2 - BACKGROUND: To identify predictors for health-related quality of life (HRQOL) in survivors of childhood brain tumors and its relationship to cognitive function. PROCEDURE: One hundred twenty-six consecutive Danish childhood brain tumor patients treated 1970-1997 and being 7.9-40.4 years at follow-up were assessed for general intelligence (IQ) and administered the Minneapolis-Manchester Quality of Life (MMQL) questionnaire. RESULTS: In multivariate linear regression treatment with RT was the most important risk factor for reduced HRQOL. Lower scores for physical functioning and energy, social functioning, cognitive functioning, body image, outlook of life, and intimate relations were significantly related to RT. Tumor location in the posterior fossa was associated with lower scores for physical functioning and energy, and tumor site in the third ventricle region was associated with lower scores for body image. Younger age at diagnosis was associated with lower scores for social functioning and intimate relations, and younger age at follow-up was associated with more physical symptoms. When IQ was included as a covariate, RT only remained significant for social functioning and intimate relations while tumor location in the third ventricle region remained significant for body image, younger age at diagnosis for social functioning and intimate relations, and younger age at follow-up for physical symptoms. In contrasts, neither gender nor presence of hydrocephalus requiring shunt inserted predicted significantly reduced HRQOL in the multivariate analyses. CONCLUSION: RT is an important predictor of HRQOL primarily due to its effect on general intelligence, which suggests that IQ is a strong determinant of HRQOL.

AB - BACKGROUND: To identify predictors for health-related quality of life (HRQOL) in survivors of childhood brain tumors and its relationship to cognitive function. PROCEDURE: One hundred twenty-six consecutive Danish childhood brain tumor patients treated 1970-1997 and being 7.9-40.4 years at follow-up were assessed for general intelligence (IQ) and administered the Minneapolis-Manchester Quality of Life (MMQL) questionnaire. RESULTS: In multivariate linear regression treatment with RT was the most important risk factor for reduced HRQOL. Lower scores for physical functioning and energy, social functioning, cognitive functioning, body image, outlook of life, and intimate relations were significantly related to RT. Tumor location in the posterior fossa was associated with lower scores for physical functioning and energy, and tumor site in the third ventricle region was associated with lower scores for body image. Younger age at diagnosis was associated with lower scores for social functioning and intimate relations, and younger age at follow-up was associated with more physical symptoms. When IQ was included as a covariate, RT only remained significant for social functioning and intimate relations while tumor location in the third ventricle region remained significant for body image, younger age at diagnosis for social functioning and intimate relations, and younger age at follow-up for physical symptoms. In contrasts, neither gender nor presence of hydrocephalus requiring shunt inserted predicted significantly reduced HRQOL in the multivariate analyses. CONCLUSION: RT is an important predictor of HRQOL primarily due to its effect on general intelligence, which suggests that IQ is a strong determinant of HRQOL.

U2 - 10.1002/pbc.22122

DO - 10.1002/pbc.22122

M3 - Journal article

C2 - 19499581

VL - 53

SP - 1086

EP - 1091

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

SN - 1545-5009

IS - 6

ER -

ID: 14913151