Glycine‐modified growth hormone secretagogues identified in seized doping material
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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Glycine‐modified growth hormone secretagogues identified in seized doping material. / Gajda, Paulina Marta; Holm, Niels Bjerre; Hoej, Lars Jakobsen; Rasmussen, Brian Schou; Dalsgaard, Petur Weihe; Reitzel, Lotte Ask; Linnet, Kristian.
I: Drug Testing and Analysis, Bind 11, Nr. 2, 02.2019, s. 350-354.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glycine‐modified growth hormone secretagogues identified in seized doping material
AU - Gajda, Paulina Marta
AU - Holm, Niels Bjerre
AU - Hoej, Lars Jakobsen
AU - Rasmussen, Brian Schou
AU - Dalsgaard, Petur Weihe
AU - Reitzel, Lotte Ask
AU - Linnet, Kristian
PY - 2019/2
Y1 - 2019/2
N2 - A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
AB - A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
KW - doping
KW - growth hormone secretagogues
KW - LC–MS
KW - modified GRF 1–29
KW - Peptide hormones
UR - http://www.scopus.com/inward/record.url?scp=85053388656&partnerID=8YFLogxK
U2 - 10.1002/dta.2489
DO - 10.1002/dta.2489
M3 - Letter
C2 - 30136411
AN - SCOPUS:85053388656
VL - 11
SP - 350
EP - 354
JO - Drug Testing and Analysis
JF - Drug Testing and Analysis
SN - 1942-7603
IS - 2
ER -
ID: 203562668