Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

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  • Patrick Munk
  • Christian Brinch
  • Frederik Duus Møller
  • Thomas N. Petersen
  • Rene S. Hendriksen
  • Anne Mette Seyfarth
  • Jette S. Kjeldgaard
  • Christina Aaby Svendsen
  • Bram van Bunnik
  • Fanny Berglund
  • Artan Bego
  • Pablo Power
  • Catherine Rees
  • Dionisia Lambrinidis
  • Neilson, Elizabeth Heather Jakobsen
  • Karen Gibb
  • Kris Coventry
  • Peter Collignon
  • Susan Cassar
  • Franz Allerberger
  • Anowara Begum
  • Zenat Zebin Hossain
  • Carlon Worrell
  • Olivier Vandenberg
  • Ilse Pieters
  • Dougnon Tamègnon Victorien
  • Angela Daniela Salazar Gutierrez
  • Freddy Soria
  • Vesna Rudić Grujić
  • Nataša Mazalica
  • Teddie O. Rahube
  • Carlos Alberto Tagliati
  • Dalia Rodrigues
  • Guilherme Oliveira
  • Larissa Camila Ribeiro de Souza
  • Ivan Ivanov
  • Bonkoungou Isidore Juste
  • Traoré Oumar
  • Thet Sopheak
  • Yith Vuthy
  • Antoinette Ngandijo
  • Ariane Nzouankeu
  • Ziem A.Abah Jacques Olivier
  • Christopher K. Yost
  • Lisbeth Truelstrup Hansen
  • Pernille Erland Jensen
  • Sivachandran Parimannan
  • Hounmanou, Yaovi Mahuton Gildas
  • Jens Thomsen
  • Frank M. Aarestrup
  • Global Sewage Surveillance Consortium
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
TidsskriftNature Communications
Antal sider16
StatusUdgivet - 2022

Bibliografisk note

Correction: 10.1038/s41467-023-35890-w
Publisher Copyright:
© 2022, The Author(s).

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