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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains : [Inkl. Correction]. / Demontis, Ditte; Walters, G. Bragi; Athanasiadis, Georgios; Walters, Raymond; Therrien, Karen; Nielsen, Trine Tollerup; Farajzadeh, Leila; Voloudakis, Georgios; Bendl, Jaroslav; Zeng, Biau; Zhang, Wen; Grove, Jakob; Als, Thomas D.; Duan, Jinjie; Satterstrom, F. Kyle; Bybjerg-Grauholm, Jonas; Bækved-Hansen, Marie; Gudmundsson, Olafur O.; Magnusson, Sigurdur H.; Baldursson, Gisli; Davidsdottir, Katrin; Haraldsdottir, Gyda S.; Agerbo, Esben; Hoffman, Gabriel E.; Dalsgaard, Søren; Martin, Joanna; Ribasés, Marta; Boomsma, Dorret I.; Soler Artigas, Maria; Roth Mota, Nina; Howrigan, Daniel; Medland, Sarah E.; Zayats, Tetyana; Rajagopal, Veera M.; Havdahl, Alexandra; Doyle, Alysa; Reif, Andreas; Thapar, Anita; Cormand, Bru; Liao, Calwing; Burton, Christie; Bau, Claiton H.D.; Rovaris, Diego Luiz; Sonuga-Barke, Edmund; Corfield, Elizabeth; Grevet, Eugenio Horacio; Larsson, Henrik; Gizer, Ian R.; Nordentoft, Merete; Werge, Thomas; ADHD Working Group of the Psychiatric Genomics Consortium; iPSYCH-Broad Consortium.
I:
Nature Genetics, Bind 55, 2023, s. 198–208.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Demontis, D, Walters, GB, Athanasiadis, G, Walters, R, Therrien, K, Nielsen, TT, Farajzadeh, L, Voloudakis, G, Bendl, J, Zeng, B, Zhang, W, Grove, J, Als, TD, Duan, J, Satterstrom, FK, Bybjerg-Grauholm, J, Bækved-Hansen, M, Gudmundsson, OO, Magnusson, SH, Baldursson, G, Davidsdottir, K, Haraldsdottir, GS, Agerbo, E, Hoffman, GE
, Dalsgaard, S, Martin, J, Ribasés, M, Boomsma, DI, Soler Artigas, M, Roth Mota, N, Howrigan, D, Medland, SE, Zayats, T, Rajagopal, VM, Havdahl, A, Doyle, A, Reif, A, Thapar, A, Cormand, B, Liao, C, Burton, C, Bau, CHD, Rovaris, DL, Sonuga-Barke, E, Corfield, E, Grevet, EH, Larsson, H, Gizer, IR
, Nordentoft, M, Werge, T, ADHD Working Group of the Psychiatric Genomics Consortium & iPSYCH-Broad Consortium 2023, '
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains: [Inkl. Correction]',
Nature Genetics, bind 55, s. 198–208.
https://doi.org/10.1038/s41588-022-01285-8APA
Demontis, D., Walters, G. B., Athanasiadis, G., Walters, R., Therrien, K., Nielsen, T. T., Farajzadeh, L., Voloudakis, G., Bendl, J., Zeng, B., Zhang, W., Grove, J., Als, T. D., Duan, J., Satterstrom, F. K., Bybjerg-Grauholm, J., Bækved-Hansen, M., Gudmundsson, O. O., Magnusson, S. H., ... iPSYCH-Broad Consortium (2023).
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains: [Inkl. Correction].
Nature Genetics,
55, 198–208.
https://doi.org/10.1038/s41588-022-01285-8Vancouver
Demontis D, Walters GB, Athanasiadis G, Walters R, Therrien K, Nielsen TT o.a.
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains: [Inkl. Correction].
Nature Genetics. 2023;55:198–208.
https://doi.org/10.1038/s41588-022-01285-8Author
Demontis, Ditte ; Walters, G. Bragi ; Athanasiadis, Georgios ; Walters, Raymond ; Therrien, Karen ; Nielsen, Trine Tollerup ; Farajzadeh, Leila ; Voloudakis, Georgios ; Bendl, Jaroslav ; Zeng, Biau ; Zhang, Wen ; Grove, Jakob ; Als, Thomas D. ; Duan, Jinjie ; Satterstrom, F. Kyle ; Bybjerg-Grauholm, Jonas ; Bækved-Hansen, Marie ; Gudmundsson, Olafur O. ; Magnusson, Sigurdur H. ; Baldursson, Gisli ; Davidsdottir, Katrin ; Haraldsdottir, Gyda S. ; Agerbo, Esben ; Hoffman, Gabriel E. ; Dalsgaard, Søren ; Martin, Joanna ; Ribasés, Marta ; Boomsma, Dorret I. ; Soler Artigas, Maria ; Roth Mota, Nina ; Howrigan, Daniel ; Medland, Sarah E. ; Zayats, Tetyana ; Rajagopal, Veera M. ; Havdahl, Alexandra ; Doyle, Alysa ; Reif, Andreas ; Thapar, Anita ; Cormand, Bru ; Liao, Calwing ; Burton, Christie ; Bau, Claiton H.D. ; Rovaris, Diego Luiz ; Sonuga-Barke, Edmund ; Corfield, Elizabeth ; Grevet, Eugenio Horacio ; Larsson, Henrik ; Gizer, Ian R. ; Nordentoft, Merete ; Werge, Thomas ; ADHD Working Group of the Psychiatric Genomics Consortium ; iPSYCH-Broad Consortium. / Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains : [Inkl. Correction]. I: Nature Genetics. 2023 ; Bind 55. s. 198–208.
Bibtex
@article{4e97603e8b6b4a60b607130cdf782191,
title = "Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains: [Inkl. Correction]",
abstract = "Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.",
author = "Ditte Demontis and Walters, {G. Bragi} and Georgios Athanasiadis and Raymond Walters and Karen Therrien and Nielsen, {Trine Tollerup} and Leila Farajzadeh and Georgios Voloudakis and Jaroslav Bendl and Biau Zeng and Wen Zhang and Jakob Grove and Als, {Thomas D.} and Jinjie Duan and Satterstrom, {F. Kyle} and Jonas Bybjerg-Grauholm and Marie B{\ae}kved-Hansen and Gudmundsson, {Olafur O.} and Magnusson, {Sigurdur H.} and Gisli Baldursson and Katrin Davidsdottir and Haraldsdottir, {Gyda S.} and Esben Agerbo and Hoffman, {Gabriel E.} and S{\o}ren Dalsgaard and Joanna Martin and Marta Ribas{\'e}s and Boomsma, {Dorret I.} and {Soler Artigas}, Maria and {Roth Mota}, Nina and Daniel Howrigan and Medland, {Sarah E.} and Tetyana Zayats and Rajagopal, {Veera M.} and Alexandra Havdahl and Alysa Doyle and Andreas Reif and Anita Thapar and Bru Cormand and Calwing Liao and Christie Burton and Bau, {Claiton H.D.} and Rovaris, {Diego Luiz} and Edmund Sonuga-Barke and Elizabeth Corfield and Grevet, {Eugenio Horacio} and Henrik Larsson and Gizer, {Ian R.} and Merete Nordentoft and Thomas Werge and {ADHD Working Group of the Psychiatric Genomics Consortium} and {iPSYCH-Broad Consortium}",
note = "Correction: 10.1038/s41588-023-01350-w Link: https://www.nature.com/articles/s41588-023-01350-w Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s41588-022-01285-8",
language = "English",
volume = "55",
pages = "198–208",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
T2 - [Inkl. Correction]
AU - Demontis, Ditte
AU - Walters, G. Bragi
AU - Athanasiadis, Georgios
AU - Walters, Raymond
AU - Therrien, Karen
AU - Nielsen, Trine Tollerup
AU - Farajzadeh, Leila
AU - Voloudakis, Georgios
AU - Bendl, Jaroslav
AU - Zeng, Biau
AU - Zhang, Wen
AU - Grove, Jakob
AU - Als, Thomas D.
AU - Duan, Jinjie
AU - Satterstrom, F. Kyle
AU - Bybjerg-Grauholm, Jonas
AU - Bækved-Hansen, Marie
AU - Gudmundsson, Olafur O.
AU - Magnusson, Sigurdur H.
AU - Baldursson, Gisli
AU - Davidsdottir, Katrin
AU - Haraldsdottir, Gyda S.
AU - Agerbo, Esben
AU - Hoffman, Gabriel E.
AU - Dalsgaard, Søren
AU - Martin, Joanna
AU - Ribasés, Marta
AU - Boomsma, Dorret I.
AU - Soler Artigas, Maria
AU - Roth Mota, Nina
AU - Howrigan, Daniel
AU - Medland, Sarah E.
AU - Zayats, Tetyana
AU - Rajagopal, Veera M.
AU - Havdahl, Alexandra
AU - Doyle, Alysa
AU - Reif, Andreas
AU - Thapar, Anita
AU - Cormand, Bru
AU - Liao, Calwing
AU - Burton, Christie
AU - Bau, Claiton H.D.
AU - Rovaris, Diego Luiz
AU - Sonuga-Barke, Edmund
AU - Corfield, Elizabeth
AU - Grevet, Eugenio Horacio
AU - Larsson, Henrik
AU - Gizer, Ian R.
AU - Nordentoft, Merete
AU - Werge, Thomas
AU - ADHD Working Group of the Psychiatric Genomics Consortium
AU - iPSYCH-Broad Consortium
N1 - Correction: 10.1038/s41588-023-01350-w
Link: https://www.nature.com/articles/s41588-023-01350-w
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023
Y1 - 2023
N2 - Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.
AB - Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention.
U2 - 10.1038/s41588-022-01285-8
DO - 10.1038/s41588-022-01285-8
M3 - Journal article
C2 - 36702997
AN - SCOPUS:85146989048
VL - 55
SP - 198
EP - 208
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -
