Genetics of cluster headache
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Genetics of cluster headache. / Gibson, Kate F.; Santos, Anita Dos; Lund, Nunu; Jensen, Rigmor; Stylianou, Ioannis M.
I: Cephalalgia, Bind 39, Nr. 10, 09.2019, s. 1298-1312.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetics of cluster headache
AU - Gibson, Kate F.
AU - Santos, Anita Dos
AU - Lund, Nunu
AU - Jensen, Rigmor
AU - Stylianou, Ioannis M.
PY - 2019/9
Y1 - 2019/9
N2 - Background: Cluster headache is the most severe primary headache disorder. A genetic basis has long been suggested by family and twin studies; however, little is understood about the genetic variants that contribute to cluster headache susceptibility. Methods: We conducted a literature search of the MEDLINE database using the PubMed search engine to identify all human genetic studies for cluster headache. In this article we provide a review of those genetic studies, along with an overview of the pathophysiology of cluster headache and a brief review of migraine genetics, which have both been significant drivers of cluster headache candidate gene selection. Results: The investigation of cluster headache genetic etiology has been dominated by candidate gene studies. Candidate selection has largely been driven by the pathophysiology, such as the striking rhythmic nature of the attacks, which spurred close examination of the circadian rhythm genes CLOCK and HCRTR2. More recently, unbiased genetic approaches such as genome-wide association studies (GWAS) have yielded new genetic avenues of interest including ADCYAP1R1 and MME. Conclusions: The majority of candidate genes studied for cluster headache suffer from poor reproducibility. Broader genetic interrogation through larger unbiased GWAS, exome, and whole genome studies may provide more robust candidates, and in turn provide a clearer understanding of the causes of cluster headache.
AB - Background: Cluster headache is the most severe primary headache disorder. A genetic basis has long been suggested by family and twin studies; however, little is understood about the genetic variants that contribute to cluster headache susceptibility. Methods: We conducted a literature search of the MEDLINE database using the PubMed search engine to identify all human genetic studies for cluster headache. In this article we provide a review of those genetic studies, along with an overview of the pathophysiology of cluster headache and a brief review of migraine genetics, which have both been significant drivers of cluster headache candidate gene selection. Results: The investigation of cluster headache genetic etiology has been dominated by candidate gene studies. Candidate selection has largely been driven by the pathophysiology, such as the striking rhythmic nature of the attacks, which spurred close examination of the circadian rhythm genes CLOCK and HCRTR2. More recently, unbiased genetic approaches such as genome-wide association studies (GWAS) have yielded new genetic avenues of interest including ADCYAP1R1 and MME. Conclusions: The majority of candidate genes studied for cluster headache suffer from poor reproducibility. Broader genetic interrogation through larger unbiased GWAS, exome, and whole genome studies may provide more robust candidates, and in turn provide a clearer understanding of the causes of cluster headache.
KW - Genetics
KW - GWAS
KW - migraine
U2 - 10.1177/0333102418815503
DO - 10.1177/0333102418815503
M3 - Review
C2 - 30917683
AN - SCOPUS:85063629938
VL - 39
SP - 1298
EP - 1312
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 10
ER -
ID: 241091220