Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation. / Mora, Cristina; Serzanti, Marialaura; Giacomelli, Alessio; Turco, Valentina; Marchina, Eleonora; Bertini, Valeria; Piovani, Giovanna; Savio, Giulia; Refsgaard, Lena; Olesen, Morten Salling; Cortellini, Venusia; Dell'Era, Patrizia.

I: Stem Cell Research, Bind 24, 10.2017, s. 29-32.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mora, C, Serzanti, M, Giacomelli, A, Turco, V, Marchina, E, Bertini, V, Piovani, G, Savio, G, Refsgaard, L, Olesen, MS, Cortellini, V & Dell'Era, P 2017, 'Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation', Stem Cell Research, bind 24, s. 29-32. https://doi.org/10.1016/j.scr.2017.08.009

APA

Mora, C., Serzanti, M., Giacomelli, A., Turco, V., Marchina, E., Bertini, V., Piovani, G., Savio, G., Refsgaard, L., Olesen, M. S., Cortellini, V., & Dell'Era, P. (2017). Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation. Stem Cell Research, 24, 29-32. https://doi.org/10.1016/j.scr.2017.08.009

Vancouver

Mora C, Serzanti M, Giacomelli A, Turco V, Marchina E, Bertini V o.a. Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation. Stem Cell Research. 2017 okt.;24:29-32. https://doi.org/10.1016/j.scr.2017.08.009

Author

Mora, Cristina ; Serzanti, Marialaura ; Giacomelli, Alessio ; Turco, Valentina ; Marchina, Eleonora ; Bertini, Valeria ; Piovani, Giovanna ; Savio, Giulia ; Refsgaard, Lena ; Olesen, Morten Salling ; Cortellini, Venusia ; Dell'Era, Patrizia. / Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation. I: Stem Cell Research. 2017 ; Bind 24. s. 29-32.

Bibtex

@article{c9d3de36c37e48888b3a82239c8cddfb,

title = "Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation",

abstract = "Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component. Indeed, genetic variations of the atrial specific KCNA5 gene have been identified in patients with early-onset lone AF. To investigate the molecular mechanisms underlying AF, we reprogrammed to pluripotency polymorphonucleated leukocytes isolated from the blood of a patient carrying a KCNA5 p.D322H mutation, using a commercially available non-integrating system. The generated iPSCs expressed pluripotency markers and differentiated toward cells belonging to the three embryonic germ layers. Moreover, the cells showed a normal karyotype and retained the p.D322H mutation.",

author = "Cristina Mora and Marialaura Serzanti and Alessio Giacomelli and Valentina Turco and Eleonora Marchina and Valeria Bertini and Giovanna Piovani and Giulia Savio and Lena Refsgaard and Olesen, {Morten Salling} and Venusia Cortellini and Patrizia Dell'Era",

year = "2017",

month = oct,

doi = "10.1016/j.scr.2017.08.009",

language = "English",

volume = "24",

pages = "29--32",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation

AU - Mora, Cristina

AU - Serzanti, Marialaura

AU - Giacomelli, Alessio

AU - Turco, Valentina

AU - Marchina, Eleonora

AU - Bertini, Valeria

AU - Piovani, Giovanna

AU - Savio, Giulia

AU - Refsgaard, Lena

AU - Olesen, Morten Salling

AU - Cortellini, Venusia

AU - Dell'Era, Patrizia

PY - 2017/10

Y1 - 2017/10

N2 - Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component. Indeed, genetic variations of the atrial specific KCNA5 gene have been identified in patients with early-onset lone AF. To investigate the molecular mechanisms underlying AF, we reprogrammed to pluripotency polymorphonucleated leukocytes isolated from the blood of a patient carrying a KCNA5 p.D322H mutation, using a commercially available non-integrating system. The generated iPSCs expressed pluripotency markers and differentiated toward cells belonging to the three embryonic germ layers. Moreover, the cells showed a normal karyotype and retained the p.D322H mutation.

AB - Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component. Indeed, genetic variations of the atrial specific KCNA5 gene have been identified in patients with early-onset lone AF. To investigate the molecular mechanisms underlying AF, we reprogrammed to pluripotency polymorphonucleated leukocytes isolated from the blood of a patient carrying a KCNA5 p.D322H mutation, using a commercially available non-integrating system. The generated iPSCs expressed pluripotency markers and differentiated toward cells belonging to the three embryonic germ layers. Moreover, the cells showed a normal karyotype and retained the p.D322H mutation.

U2 - 10.1016/j.scr.2017.08.009

DO - 10.1016/j.scr.2017.08.009

M3 - Journal article

C2 - 29034891

VL - 24

SP - 29

EP - 32

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

ER -

ID: 196039259