Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.
Originalsprog | Engelsk |
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Tidsskrift | Diabetologia |
Vol/bind | 47 |
Udgave nummer | 12 |
Sider (fra-til) | 2185-99 |
Antal sider | 15 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - dec. 2004 |
Eksternt udgivet | Ja |
ID: 46485091