Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs. / Blirup-Plum, Sophie Amalie; Jensen, Henrik Elvang; Nielsen, Søren Saxmose; Pankoke, Karen; Hansen, Mette Sif; Pedersen, Ken Steen; Eriksen, Esben Østergaard; Nielsen, Jens Peter; Olsen, John Elmerdahl; Kudirkiene, Egle; Larsen, Lars Erik; Goecke, Nicole Bakkegård; Barington, Kristiane.
I: Acta Veterinaria Scandinavica, Bind 65, 30, 2023, s. 1-18.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs
AU - Blirup-Plum, Sophie Amalie
AU - Jensen, Henrik Elvang
AU - Nielsen, Søren Saxmose
AU - Pankoke, Karen
AU - Hansen, Mette Sif
AU - Pedersen, Ken Steen
AU - Eriksen, Esben Østergaard
AU - Nielsen, Jens Peter
AU - Olsen, John Elmerdahl
AU - Kudirkiene, Egle
AU - Larsen, Lars Erik
AU - Goecke, Nicole Bakkegård
AU - Barington, Kristiane
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Background: Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause is enterotoxigenic Escherichia coli. The objective of the study was to investigate possible associations between pathological manifestations and pathogens in pigs with and without PWD. The study was conducted as a case–control study and included a total of 173 pigs from 9 different commercial intensive indoor production herds in eastern Denmark. Results: Based on clinical examination, a total of 89 piglets with PWD (cases) and 84 piglets without PWD (controls) were included. Most of the pigs (n = 105/173) presented gastric lesions, which were more frequently observed in the control group. The odds of gastric ulcers were lower among pigs with PWD compared to pigs without PWD with an odds ratio (OR) of 0.2 (0.0; 0.7). Abnormal content in the colon was associated with PWD, with an OR of 6.5 (3.2; 14.3). No apparent association was found between lesions and the various pathogens or a combination of these. The odds of neutrophilic granulocyte infiltration were lower in the jejunum among pigs with PWD (OR 0.3 [0.1; 0.6]) compared to pigs without PWD. The association between neutrophilic granulocyte infiltration in jejunum and PWD differed between the herds (P = 0.03). Furthermore, the associations between PWD and hyperleukocytosis (P = 0.04) or infiltration of eosinophilic granulocytes (P = 0.04) in ileum were also herd dependent. Histopathology revealed several lesions not relatable to PWD. Conclusion: The association between lesions and specific pathogens or PWD is more complex than anticipated.
AB - Background: Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause is enterotoxigenic Escherichia coli. The objective of the study was to investigate possible associations between pathological manifestations and pathogens in pigs with and without PWD. The study was conducted as a case–control study and included a total of 173 pigs from 9 different commercial intensive indoor production herds in eastern Denmark. Results: Based on clinical examination, a total of 89 piglets with PWD (cases) and 84 piglets without PWD (controls) were included. Most of the pigs (n = 105/173) presented gastric lesions, which were more frequently observed in the control group. The odds of gastric ulcers were lower among pigs with PWD compared to pigs without PWD with an odds ratio (OR) of 0.2 (0.0; 0.7). Abnormal content in the colon was associated with PWD, with an OR of 6.5 (3.2; 14.3). No apparent association was found between lesions and the various pathogens or a combination of these. The odds of neutrophilic granulocyte infiltration were lower in the jejunum among pigs with PWD (OR 0.3 [0.1; 0.6]) compared to pigs without PWD. The association between neutrophilic granulocyte infiltration in jejunum and PWD differed between the herds (P = 0.03). Furthermore, the associations between PWD and hyperleukocytosis (P = 0.04) or infiltration of eosinophilic granulocytes (P = 0.04) in ileum were also herd dependent. Histopathology revealed several lesions not relatable to PWD. Conclusion: The association between lesions and specific pathogens or PWD is more complex than anticipated.
KW - Histopathology
KW - Microbiology
KW - Pigs
KW - Post-weaning diarrhoea
U2 - 10.1186/s13028-023-00693-y
DO - 10.1186/s13028-023-00693-y
M3 - Journal article
C2 - 37400879
AN - SCOPUS:85164028402
VL - 65
SP - 1
EP - 18
JO - Acta Veterinaria Scandinavica
JF - Acta Veterinaria Scandinavica
SN - 0044-605X
M1 - 30
ER -
ID: 360984979