Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

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Standard

Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats. / Hankir, Mohammed K; Seyfried, Florian; Hintschich, Constantin A; Diep, Thi-Ai; Kleberg, Karen; Kranz, Mathias; Deuther-Conrad, Winnie; Tellez, Luis A; Rullmann, Michael; Patt, Marianne; Teichert, Jens; Hesse, Swen; Sabri, Osama; Brust, Peter; Hansen, Harald S; de Araujo, Ivan E; Krügel, Ute; Fenske, Wiebke K.

I: Cell Metabolism, Bind 25, Nr. 2, 07.02.2017, s. 335-344.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hankir, MK, Seyfried, F, Hintschich, CA, Diep, T-A, Kleberg, K, Kranz, M, Deuther-Conrad, W, Tellez, LA, Rullmann, M, Patt, M, Teichert, J, Hesse, S, Sabri, O, Brust, P, Hansen, HS, de Araujo, IE, Krügel, U & Fenske, WK 2017, 'Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats', Cell Metabolism, bind 25, nr. 2, s. 335-344. https://doi.org/10.1016/j.cmet.2016.12.006

APA

Hankir, M. K., Seyfried, F., Hintschich, C. A., Diep, T-A., Kleberg, K., Kranz, M., Deuther-Conrad, W., Tellez, L. A., Rullmann, M., Patt, M., Teichert, J., Hesse, S., Sabri, O., Brust, P., Hansen, H. S., de Araujo, I. E., Krügel, U., & Fenske, W. K. (2017). Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats. Cell Metabolism, 25(2), 335-344. https://doi.org/10.1016/j.cmet.2016.12.006

Vancouver

Hankir MK, Seyfried F, Hintschich CA, Diep T-A, Kleberg K, Kranz M o.a. Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats. Cell Metabolism. 2017 feb. 7;25(2):335-344. https://doi.org/10.1016/j.cmet.2016.12.006

Author

Hankir, Mohammed K ; Seyfried, Florian ; Hintschich, Constantin A ; Diep, Thi-Ai ; Kleberg, Karen ; Kranz, Mathias ; Deuther-Conrad, Winnie ; Tellez, Luis A ; Rullmann, Michael ; Patt, Marianne ; Teichert, Jens ; Hesse, Swen ; Sabri, Osama ; Brust, Peter ; Hansen, Harald S ; de Araujo, Ivan E ; Krügel, Ute ; Fenske, Wiebke K. / Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats. I: Cell Metabolism. 2017 ; Bind 25, Nr. 2. s. 335-344.

Bibtex

@article{a83e83e125c443f891713daec7b6d321,

title = "Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats",

abstract = "Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus nerve-driven increases in dorsal striatal dopamine release. We also demonstrate that RYGB upregulates striatal dopamine 1 receptor (D1R) expression specifically under high-fat diet feeding conditions. Mechanistically, interfering with local OEA, vagal, and dorsal striatal D1R signaling negated the beneficial effects of RYGB on fat intake and preferences. These findings delineate a molecular/systems pathway through which bariatric surgery improves feeding behavior and may aid in the development of novel weight loss strategies that similarly modify brain reward circuits compromised in obesity.",

keywords = "Journal Article",

author = "Hankir, {Mohammed K} and Florian Seyfried and Hintschich, {Constantin A} and Thi-Ai Diep and Karen Kleberg and Mathias Kranz and Winnie Deuther-Conrad and Tellez, {Luis A} and Michael Rullmann and Marianne Patt and Jens Teichert and Swen Hesse and Osama Sabri and Peter Brust and Hansen, {Harald S} and {de Araujo}, {Ivan E} and Ute Kr{\"u}gel and Fenske, {Wiebke K}",

year = "2017",

month = feb,

day = "7",

doi = "10.1016/j.cmet.2016.12.006",

language = "English",

volume = "25",

pages = "335--344",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "2",

}

RIS

TY - JOUR

T1 - Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

AU - Hankir, Mohammed K

AU - Seyfried, Florian

AU - Hintschich, Constantin A

AU - Diep, Thi-Ai

AU - Kleberg, Karen

AU - Kranz, Mathias

AU - Deuther-Conrad, Winnie

AU - Tellez, Luis A

AU - Rullmann, Michael

AU - Patt, Marianne

AU - Teichert, Jens

AU - Hesse, Swen

AU - Sabri, Osama

AU - Brust, Peter

AU - Hansen, Harald S

AU - de Araujo, Ivan E

AU - Krügel, Ute

AU - Fenske, Wiebke K

PY - 2017/2/7

Y1 - 2017/2/7

N2 - Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus nerve-driven increases in dorsal striatal dopamine release. We also demonstrate that RYGB upregulates striatal dopamine 1 receptor (D1R) expression specifically under high-fat diet feeding conditions. Mechanistically, interfering with local OEA, vagal, and dorsal striatal D1R signaling negated the beneficial effects of RYGB on fat intake and preferences. These findings delineate a molecular/systems pathway through which bariatric surgery improves feeding behavior and may aid in the development of novel weight loss strategies that similarly modify brain reward circuits compromised in obesity.

AB - Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus nerve-driven increases in dorsal striatal dopamine release. We also demonstrate that RYGB upregulates striatal dopamine 1 receptor (D1R) expression specifically under high-fat diet feeding conditions. Mechanistically, interfering with local OEA, vagal, and dorsal striatal D1R signaling negated the beneficial effects of RYGB on fat intake and preferences. These findings delineate a molecular/systems pathway through which bariatric surgery improves feeding behavior and may aid in the development of novel weight loss strategies that similarly modify brain reward circuits compromised in obesity.

KW - Journal Article

U2 - 10.1016/j.cmet.2016.12.006

DO - 10.1016/j.cmet.2016.12.006

M3 - Journal article

C2 - 28065827

VL - 25

SP - 335

EP - 344

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 2

ER -

ID: 174431099