Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy
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Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy. / Enevoldsen, Lotte Hahn; Tindborg, Marie; Hovmand, Nichlas Lindegaard; Christoffersen, Christina; Ellingsgaard, Helga; Suetta, Charlotte; Stallknecht, Bente Merete; Jennum, Poul Joergen; Kjær, Andreas; Gammeltoft, Steen.
I: Sleep, Bind 41, Nr. 8, zsy092, 2018, s. 1-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy
AU - Enevoldsen, Lotte Hahn
AU - Tindborg, Marie
AU - Hovmand, Nichlas Lindegaard
AU - Christoffersen, Christina
AU - Ellingsgaard, Helga
AU - Suetta, Charlotte
AU - Stallknecht, Bente Merete
AU - Jennum, Poul Joergen
AU - Kjær, Andreas
AU - Gammeltoft, Steen
PY - 2018
Y1 - 2018
N2 - Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy.Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively. Plasma levels of eight hormones regulating BAT activity were measured before and after 2 h in the cold.Results: 18F-FDG-uptake and uptake of 123I-MIBG in BAT after 2 h cold exposure was observed in all individuals, but the activity of BAT was not significantly different between type 1 narcolepsy patients and healthy controls (p>0.05). Plasma levels of GLP-1 were higher in type 1 narcolepsy patients compared with controls (p<0.05), but not altered by cold adaptation in patients and controls (p>0.05). FGF21 concentrations decreased after 2 h cold exposure in both type 1 narcolepsy patients and healthy subjects (p<0.05).Conclusions: Sympathetic and metabolic activity of BAT was observed after cold exposure in patients with type 1 narcolepsy. Increased GLP-1 in narcolepsy may suggest autonomic dysfunction with metabolic changes. We conclude that BAT is functional after cold exposure in spite of the loss of orexinergic neurons in narcolepsy.
AB - Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy.Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively. Plasma levels of eight hormones regulating BAT activity were measured before and after 2 h in the cold.Results: 18F-FDG-uptake and uptake of 123I-MIBG in BAT after 2 h cold exposure was observed in all individuals, but the activity of BAT was not significantly different between type 1 narcolepsy patients and healthy controls (p>0.05). Plasma levels of GLP-1 were higher in type 1 narcolepsy patients compared with controls (p<0.05), but not altered by cold adaptation in patients and controls (p>0.05). FGF21 concentrations decreased after 2 h cold exposure in both type 1 narcolepsy patients and healthy subjects (p<0.05).Conclusions: Sympathetic and metabolic activity of BAT was observed after cold exposure in patients with type 1 narcolepsy. Increased GLP-1 in narcolepsy may suggest autonomic dysfunction with metabolic changes. We conclude that BAT is functional after cold exposure in spite of the loss of orexinergic neurons in narcolepsy.
U2 - 10.1093/sleep/zsy092
DO - 10.1093/sleep/zsy092
M3 - Journal article
C2 - 29771387
VL - 41
SP - 1
EP - 9
JO - Sleep (Online)
JF - Sleep (Online)
SN - 0161-8105
IS - 8
M1 - zsy092
ER -
ID: 198408094