TY - JOUR

T1 - Fuel metabolism in a pig myocutaneous island flap model

AU - Hjortdal, V E

AU - Kjølseth, D

AU - Henriksen, T B

AU - Hansen, E S

AU - Møller, N

PY - 1991/10

Y1 - 1991/10

N2 - Unilateral denervated myocutaneous island flaps based on the superior epigastric vessels were raised in 24 pigs and the metabolic changes during the first 6 postoperative hours were monitored. Secondary to flap elevation, decreased arteriovenous (A-V) differences in oxygen, glucose, and alanine levels were observed, indicating the opening of A-V shunts and increased arterialization of the venous blood. Venous outflow increased during the first 3 hours, but the A-V differences in all metabolites were constant over the entire 6-hour observation period. Exchange of intermediary metabolites therefore increased within the first 3 hours, after which a steady state was established. The main flap fuels seemed to be fatty acids, muscle proteins, and glycogen, whereas blood-borne carbohydrates and ketone bodies played only a minor role as energy sources. Anaerobic metabolism was increased secondary to flap elevation from 2 to 6 percent as compared with preelevation values. No changes were found in concentrations of plasma catecholamines, which were constantly high. An average weight gain of 3 to 4 percent per hour was equally distributed to skin, subcutis, panniculus carnosus, and muscle. Thus the flap seemed to adapt to the new perfusion pattern within a few hours by a slightly increased anaerobic metabolism, but still with an oxidative metabolism of more than 90 percent.

AB - Unilateral denervated myocutaneous island flaps based on the superior epigastric vessels were raised in 24 pigs and the metabolic changes during the first 6 postoperative hours were monitored. Secondary to flap elevation, decreased arteriovenous (A-V) differences in oxygen, glucose, and alanine levels were observed, indicating the opening of A-V shunts and increased arterialization of the venous blood. Venous outflow increased during the first 3 hours, but the A-V differences in all metabolites were constant over the entire 6-hour observation period. Exchange of intermediary metabolites therefore increased within the first 3 hours, after which a steady state was established. The main flap fuels seemed to be fatty acids, muscle proteins, and glycogen, whereas blood-borne carbohydrates and ketone bodies played only a minor role as energy sources. Anaerobic metabolism was increased secondary to flap elevation from 2 to 6 percent as compared with preelevation values. No changes were found in concentrations of plasma catecholamines, which were constantly high. An average weight gain of 3 to 4 percent per hour was equally distributed to skin, subcutis, panniculus carnosus, and muscle. Thus the flap seemed to adapt to the new perfusion pattern within a few hours by a slightly increased anaerobic metabolism, but still with an oxidative metabolism of more than 90 percent.

KW - 3-Hydroxybutyric Acid

KW - Alanine/blood

KW - Animals

KW - Blood Glucose/analysis

KW - Body Temperature

KW - Epinephrine/blood

KW - Glucagon/blood

KW - Glucose/metabolism

KW - Glycerol/blood

KW - Hydroxybutyrates/blood

KW - Insulin/blood

KW - Lactates/blood

KW - Muscles/blood supply

KW - Norepinephrine/blood

KW - Oxygen/blood

KW - Regional Blood Flow

KW - Skin/blood supply

KW - Surgical Flaps

KW - Swine

U2 - 10.1097/00006534-199110000-00017

DO - 10.1097/00006534-199110000-00017

M3 - Journal article

C2 - 1896538

VL - 88

SP - 664

EP - 672

JO - Plastic and Reconstructive Surgery

JF - Plastic and Reconstructive Surgery

SN - 0032-1052

IS - 4

ER -