Bibliografisk note

Funding Information:
We thank Dr. Birgitte Andersen (Novo Nordisk) for providing FGF21 protein. We thank Pfizer for providing PF-05231023. This work was funded by the National Institutes of Health (NIH) R01DK106104 (M.J.P.), R01AA027654 (M.J.P.), and T32 DK112751 (K.H.F.); Brain Behavior Research Foundation Young Investigator Award 28026 (K.H.F.), F32 DK117510 (K.E.C.), F31 DK117515 (S.O.J.-C.), and DK126740 (D.A.); Veterans Affairs Merit Review Program I01BX004634 (M.J.P.); the University of Iowa Carver College of Medicine (M.J.P.); the Novo Nordisk Foundation Center for Basic Metabolic Research NNF18CC003490 (M.P.G.); the Danish Council for Independent Research 0134-00375B ; and the Novo Nordisk Foundation Metabolite Consortium 0064142. Some of the data presented herein were obtained at the Flow Cytometry Facility supported by the NIH ( 1 S10 OD016199-01A1 ). The authors would like to acknowledge the University of Iowa Central Microscopy Research Facility and Genome Editing Facility, the Genomics Division of the Iowa Institute of Human Genetics, and the Iowa Neuroscience Institute Neural Circuits and Behavior Core. Some figures included illustrations made using https://biorender.com/ .

Funding Information:
We thank Dr. Birgitte Andersen (Novo Nordisk) for providing FGF21 protein. We thank Pfizer for providing PF-05231023. This work was funded by the National Institutes of Health (NIH) R01DK106104 (M.J.P.), R01AA027654 (M.J.P.), and T32 DK112751 (K.H.F.); Brain Behavior Research Foundation Young Investigator Award 28026 (K.H.F.), F32 DK117510 (K.E.C.), F31 DK117515 (S.O.J.-C.), and DK126740 (D.A.); Veterans Affairs Merit Review Program I01BX004634 (M.J.P.); the University of Iowa Carver College of Medicine (M.J.P.); the Novo Nordisk Foundation Center for Basic Metabolic Research NNF18CC003490 (M.P.G.); the Danish Council for Independent Research 0134-00375B; and the Novo Nordisk Foundation Metabolite Consortium 0064142. Some of the data presented herein were obtained at the Flow Cytometry Facility supported by the NIH (1 S10 OD016199-01A1). The authors would like to acknowledge the University of Iowa Central Microscopy Research Facility and Genome Editing Facility, the Genomics Division of the Iowa Institute of Human Genetics, and the Iowa Neuroscience Institute Neural Circuits and Behavior Core. Some figures included illustrations made using https://biorender.com/. M.J.P. and K.H.F. conceived of the project, designed experiments, interpreted data, wrote the paper, and are responsible for the integrity of its content. S.A.J.T. and M.P.G. conceived of the project, designed and performed experiments, and interpreted data. I.A. Y.Y. S.O.J.-C. M.B.P. B.Z. K.E.C. A.B. A.F.-J. N.K.S. F.K.K. R.M.P. B.A.G. and D.A. performed experiments and interpreted data. Recombinant human FGF21 protein was provided by Novo Nordisk, and PF-05231023 was provided by Pfizer. Neither Novo Nordisk nor Pfizer was involved with the conceptualization, design, data collection, analysis, or preparation of the manuscript. Correspondence and requests for materials should be addressed to M.J.P. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. One or more of the authors of this paper received support from a program designed to increase minority representation in science.

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