Familial hypercholesterolaemia: cholesterol efflux and coronary disease

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Familial hypercholesterolaemia : cholesterol efflux and coronary disease. / Versmissen, Jorie; Vongpromek, Ranitha; Yahya, Reyhana; van der Net, Jeroen B; van Vark-van der Zee, Leonie; Blommesteijn-Touw, Jeannette; Wattimena, Darcos; Rietveld, Trinet; Pullinger, Clive R; Christoffersen, Christina; Dahlbäck, Björn; Kane, John P; Mulder, Monique; Sijbrands, Eric J G.

I: European Journal of Clinical Investigation, Bind 46, Nr. 7, 07.2016, s. 643-50.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Versmissen, J, Vongpromek, R, Yahya, R, van der Net, JB, van Vark-van der Zee, L, Blommesteijn-Touw, J, Wattimena, D, Rietveld, T, Pullinger, CR, Christoffersen, C, Dahlbäck, B, Kane, JP, Mulder, M & Sijbrands, EJG 2016, 'Familial hypercholesterolaemia: cholesterol efflux and coronary disease', European Journal of Clinical Investigation, bind 46, nr. 7, s. 643-50. https://doi.org/10.1111/eci.12643

APA

Versmissen, J., Vongpromek, R., Yahya, R., van der Net, J. B., van Vark-van der Zee, L., Blommesteijn-Touw, J., Wattimena, D., Rietveld, T., Pullinger, C. R., Christoffersen, C., Dahlbäck, B., Kane, J. P., Mulder, M., & Sijbrands, E. J. G. (2016). Familial hypercholesterolaemia: cholesterol efflux and coronary disease. European Journal of Clinical Investigation, 46(7), 643-50. https://doi.org/10.1111/eci.12643

Vancouver

Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J o.a. Familial hypercholesterolaemia: cholesterol efflux and coronary disease. European Journal of Clinical Investigation. 2016 jul;46(7):643-50. https://doi.org/10.1111/eci.12643

Author

Versmissen, Jorie ; Vongpromek, Ranitha ; Yahya, Reyhana ; van der Net, Jeroen B ; van Vark-van der Zee, Leonie ; Blommesteijn-Touw, Jeannette ; Wattimena, Darcos ; Rietveld, Trinet ; Pullinger, Clive R ; Christoffersen, Christina ; Dahlbäck, Björn ; Kane, John P ; Mulder, Monique ; Sijbrands, Eric J G. / Familial hypercholesterolaemia : cholesterol efflux and coronary disease. I: European Journal of Clinical Investigation. 2016 ; Bind 46, Nr. 7. s. 643-50.

Bibtex

@article{0bb9b87f4030421ab3c0c5927895e03e,
title = "Familial hypercholesterolaemia: cholesterol efflux and coronary disease",
abstract = "BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.",
keywords = "Journal Article",
author = "Jorie Versmissen and Ranitha Vongpromek and Reyhana Yahya and {van der Net}, {Jeroen B} and {van Vark-van der Zee}, Leonie and Jeannette Blommesteijn-Touw and Darcos Wattimena and Trinet Rietveld and Pullinger, {Clive R} and Christina Christoffersen and Bj{\"o}rn Dahlb{\"a}ck and Kane, {John P} and Monique Mulder and Sijbrands, {Eric J G}",
note = "{\textcopyright} 2016 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.",
year = "2016",
month = jul,
doi = "10.1111/eci.12643",
language = "English",
volume = "46",
pages = "643--50",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Familial hypercholesterolaemia

T2 - cholesterol efflux and coronary disease

AU - Versmissen, Jorie

AU - Vongpromek, Ranitha

AU - Yahya, Reyhana

AU - van der Net, Jeroen B

AU - van Vark-van der Zee, Leonie

AU - Blommesteijn-Touw, Jeannette

AU - Wattimena, Darcos

AU - Rietveld, Trinet

AU - Pullinger, Clive R

AU - Christoffersen, Christina

AU - Dahlbäck, Björn

AU - Kane, John P

AU - Mulder, Monique

AU - Sijbrands, Eric J G

N1 - © 2016 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

PY - 2016/7

Y1 - 2016/7

N2 - BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

AB - BACKGROUND: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux.MATERIALS AND METHODS: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM).RESULTS: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers.CONCLUSIONS: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

KW - Journal Article

U2 - 10.1111/eci.12643

DO - 10.1111/eci.12643

M3 - Journal article

C2 - 27208892

VL - 46

SP - 643

EP - 650

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 7

ER -

ID: 172616973