Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Pediatric Hematology/Oncology |
Vol/bind | 46 |
Udgave nummer | 1 |
Sider (fra-til) | E111-E114 |
ISSN | 1077-4114 |
DOI | |
Status | Udgivet - 1 jan. 2024 |
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ID: 398644067