Extramedullary relapse in a patient with multiple myeloma: A rare cause of gastrointestinal perforation and massive bleeding

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Standard

Extramedullary relapse in a patient with multiple myeloma : A rare cause of gastrointestinal perforation and massive bleeding. / Rene, Christoffer Galletta; Achiam, Michael Patrick; Salomo, Morten; Penninga, Luit.

I: BMJ Case Reports, Bind 14, Nr. 11, 243663, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rene, CG, Achiam, MP, Salomo, M & Penninga, L 2021, 'Extramedullary relapse in a patient with multiple myeloma: A rare cause of gastrointestinal perforation and massive bleeding', BMJ Case Reports, bind 14, nr. 11, 243663. https://doi.org/10.1136/bcr-2021-243663

APA

Rene, C. G., Achiam, M. P., Salomo, M., & Penninga, L. (2021). Extramedullary relapse in a patient with multiple myeloma: A rare cause of gastrointestinal perforation and massive bleeding. BMJ Case Reports, 14(11), [243663]. https://doi.org/10.1136/bcr-2021-243663

Vancouver

Rene CG, Achiam MP, Salomo M, Penninga L. Extramedullary relapse in a patient with multiple myeloma: A rare cause of gastrointestinal perforation and massive bleeding. BMJ Case Reports. 2021;14(11). 243663. https://doi.org/10.1136/bcr-2021-243663

Author

Rene, Christoffer Galletta ; Achiam, Michael Patrick ; Salomo, Morten ; Penninga, Luit. / Extramedullary relapse in a patient with multiple myeloma : A rare cause of gastrointestinal perforation and massive bleeding. I: BMJ Case Reports. 2021 ; Bind 14, Nr. 11.

Bibtex

@article{6028fda624eb4adbbe08d920a619066f,
title = "Extramedullary relapse in a patient with multiple myeloma: A rare cause of gastrointestinal perforation and massive bleeding",
abstract = "Multiple myeloma (MM) patients live longer due to more effective treatment, and we now see previously uncommon manifestations of MM, like extramedullary disease. We present a case of a 74-year-old man known with MM that relapsed with extramedullary manifestations at different locations. One of them as a gastric plasmacytoma (GP). He was successfully treated with chemoradiotherapy (Daratumumab, Bortezomib and Dexamethasone), which resulted in clinical response for 8 months, confirmed by biopsy and histopathology. Perforation of the GP occurred, and he underwent partial gastrectomy (Billroth II gastrojejunostomy). The patient's disease progressed again 5 months after surgery, and he did not want any additional treatment. He accepted palliative care and died 10 months after the operation. A lack of knowledge about the characteristics and treatment of extramedullary MM exists, and prospective studies to investigate incidence, prognosis and treatment for extramedullary MM are needed for improving the poor prognosis of this manifestation. ",
keywords = "gastrointestinal surgery, general surgery, haematology (incl blood transfusion), ulcer",
author = "Rene, {Christoffer Galletta} and Achiam, {Michael Patrick} and Morten Salomo and Luit Penninga",
note = "Publisher Copyright: {\textcopyright} ",
year = "2021",
doi = "10.1136/bcr-2021-243663",
language = "English",
volume = "14",
journal = "BMJ Case Reports",
issn = "1757-790X",
publisher = "BMJ Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Extramedullary relapse in a patient with multiple myeloma

T2 - A rare cause of gastrointestinal perforation and massive bleeding

AU - Rene, Christoffer Galletta

AU - Achiam, Michael Patrick

AU - Salomo, Morten

AU - Penninga, Luit

N1 - Publisher Copyright: ©

PY - 2021

Y1 - 2021

N2 - Multiple myeloma (MM) patients live longer due to more effective treatment, and we now see previously uncommon manifestations of MM, like extramedullary disease. We present a case of a 74-year-old man known with MM that relapsed with extramedullary manifestations at different locations. One of them as a gastric plasmacytoma (GP). He was successfully treated with chemoradiotherapy (Daratumumab, Bortezomib and Dexamethasone), which resulted in clinical response for 8 months, confirmed by biopsy and histopathology. Perforation of the GP occurred, and he underwent partial gastrectomy (Billroth II gastrojejunostomy). The patient's disease progressed again 5 months after surgery, and he did not want any additional treatment. He accepted palliative care and died 10 months after the operation. A lack of knowledge about the characteristics and treatment of extramedullary MM exists, and prospective studies to investigate incidence, prognosis and treatment for extramedullary MM are needed for improving the poor prognosis of this manifestation.

AB - Multiple myeloma (MM) patients live longer due to more effective treatment, and we now see previously uncommon manifestations of MM, like extramedullary disease. We present a case of a 74-year-old man known with MM that relapsed with extramedullary manifestations at different locations. One of them as a gastric plasmacytoma (GP). He was successfully treated with chemoradiotherapy (Daratumumab, Bortezomib and Dexamethasone), which resulted in clinical response for 8 months, confirmed by biopsy and histopathology. Perforation of the GP occurred, and he underwent partial gastrectomy (Billroth II gastrojejunostomy). The patient's disease progressed again 5 months after surgery, and he did not want any additional treatment. He accepted palliative care and died 10 months after the operation. A lack of knowledge about the characteristics and treatment of extramedullary MM exists, and prospective studies to investigate incidence, prognosis and treatment for extramedullary MM are needed for improving the poor prognosis of this manifestation.

KW - gastrointestinal surgery

KW - general surgery

KW - haematology (incl blood transfusion)

KW - ulcer

U2 - 10.1136/bcr-2021-243663

DO - 10.1136/bcr-2021-243663

M3 - Journal article

C2 - 34794974

AN - SCOPUS:85120354566

VL - 14

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

IS - 11

M1 - 243663

ER -

ID: 304077196