Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?

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Standard

Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? / Rossen, K; Dahlstrøm, K K; Mercurio, A M; Wewer, U M.

I: Acta Dermato Venereologica, Bind 74, Nr. 2, 01.03.1994, s. 101-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rossen, K, Dahlstrøm, KK, Mercurio, AM & Wewer, UM 1994, 'Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?', Acta Dermato Venereologica, bind 74, nr. 2, s. 101-5.

APA

Rossen, K., Dahlstrøm, K. K., Mercurio, A. M., & Wewer, U. M. (1994). Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? Acta Dermato Venereologica, 74(2), 101-5.

Vancouver

Rossen K, Dahlstrøm KK, Mercurio AM, Wewer UM. Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential? Acta Dermato Venereologica. 1994 mar. 1;74(2):101-5.

Author

Rossen, K ; Dahlstrøm, K K ; Mercurio, A M ; Wewer, U M. / Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?. I: Acta Dermato Venereologica. 1994 ; Bind 74, Nr. 2. s. 101-5.

Bibtex

@article{9b4bedb042174108bba7df7105ecb330,
title = "Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?",
abstract = "We have studied the expression of alpha 6 beta 4 integrin, a carcinoma laminin receptor in ten squamous cell carcinomas (SCCs) and ten basal cell carcinomas (BCCs) of the skin in order to examine whether changes in alpha 6 beta 4 integrin expression may be related to invasive and metastatic potential. Monoclonal antibodies specific for each subunit were applied on cryosections, using a three step indirect peroxidase technique. In normal epidermis the basal cells expressed both the alpha 6 and the beta 4 subunits, and the expression was polarized against the basement membrane. In SCCs the expression of the alpha 6 and the beta 4 subunits paralleled each other, showing an increased intensity and loss of polarity. The BCCs, however, showed consistently decreased expression of both the alpha 6 and the beta 4 subunits. The results of our study, as well as those of other studies, support the assumption that the increase and depolarization of alpha 6 beta 4 integrin that occurs in SCCs might be related to the invasive properties of this tumour type.",
keywords = "Antigens, Neoplasm, Antigens, Surface, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Humans, Immunohistochemistry, Integrin alpha6beta4, Integrins, Neoplasm Invasiveness, Neoplasm Metastasis, Skin Neoplasms",
author = "K Rossen and Dahlstr{\o}m, {K K} and Mercurio, {A M} and Wewer, {U M}",
year = "1994",
month = mar,
day = "1",
language = "English",
volume = "74",
pages = "101--5",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "2",

}

RIS

TY - JOUR

T1 - Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?

AU - Rossen, K

AU - Dahlstrøm, K K

AU - Mercurio, A M

AU - Wewer, U M

PY - 1994/3/1

Y1 - 1994/3/1

N2 - We have studied the expression of alpha 6 beta 4 integrin, a carcinoma laminin receptor in ten squamous cell carcinomas (SCCs) and ten basal cell carcinomas (BCCs) of the skin in order to examine whether changes in alpha 6 beta 4 integrin expression may be related to invasive and metastatic potential. Monoclonal antibodies specific for each subunit were applied on cryosections, using a three step indirect peroxidase technique. In normal epidermis the basal cells expressed both the alpha 6 and the beta 4 subunits, and the expression was polarized against the basement membrane. In SCCs the expression of the alpha 6 and the beta 4 subunits paralleled each other, showing an increased intensity and loss of polarity. The BCCs, however, showed consistently decreased expression of both the alpha 6 and the beta 4 subunits. The results of our study, as well as those of other studies, support the assumption that the increase and depolarization of alpha 6 beta 4 integrin that occurs in SCCs might be related to the invasive properties of this tumour type.

AB - We have studied the expression of alpha 6 beta 4 integrin, a carcinoma laminin receptor in ten squamous cell carcinomas (SCCs) and ten basal cell carcinomas (BCCs) of the skin in order to examine whether changes in alpha 6 beta 4 integrin expression may be related to invasive and metastatic potential. Monoclonal antibodies specific for each subunit were applied on cryosections, using a three step indirect peroxidase technique. In normal epidermis the basal cells expressed both the alpha 6 and the beta 4 subunits, and the expression was polarized against the basement membrane. In SCCs the expression of the alpha 6 and the beta 4 subunits paralleled each other, showing an increased intensity and loss of polarity. The BCCs, however, showed consistently decreased expression of both the alpha 6 and the beta 4 subunits. The results of our study, as well as those of other studies, support the assumption that the increase and depolarization of alpha 6 beta 4 integrin that occurs in SCCs might be related to the invasive properties of this tumour type.

KW - Antigens, Neoplasm

KW - Antigens, Surface

KW - Carcinoma, Basal Cell

KW - Carcinoma, Squamous Cell

KW - Humans

KW - Immunohistochemistry

KW - Integrin alpha6beta4

KW - Integrins

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Skin Neoplasms

M3 - Journal article

C2 - 7911612

VL - 74

SP - 101

EP - 105

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 2

ER -

ID: 34326189