Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling
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Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling. / Flaxman, Teresa E.; Shourijeh, Mohammad S.; Alkjær, Tine; Krogsgaard, Michael R.; Simonsen, Erik B.; Bigham, Heather; Benoit, Daniel L.
I: Clinical biomechanics (Bristol, Avon), Bind 67, 2019, s. 27-33.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Experimental muscle pain of the vastus medialis reduces knee joint extensor torque and alters quadriceps muscle contributions as revealed through musculoskeletal modeling
AU - Flaxman, Teresa E.
AU - Shourijeh, Mohammad S.
AU - Alkjær, Tine
AU - Krogsgaard, Michael R.
AU - Simonsen, Erik B.
AU - Bigham, Heather
AU - Benoit, Daniel L.
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.
AB - BACKGROUND: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extensor inhibition and muscle force contributions to isometric knee joint torques in healthy adults with and without experimentally induced quadriceps muscle pain.METHODS: A randomized cross-over placebo controlled study design was used. Subject-specific maximum knee joint extension torque and quadriceps electromyographic data from 13 uninjured young adults were combined in a modeling framework to determine optimal muscle strength scaling parameters and ideal torque. Strength deficit ratios (experimental torque/ideal torque) and individual muscle contribution to experimental torque was computed before and after intramuscular hypertonic (pain inducing) and isotonic (sham) saline was injected to the vastus medialis.FINDINGS: Decreased experimental knee extension torque (-8%) and vastus medialis electromyography (-26%) amplitude pre- to post- hypertonic injection was observed. Correspondingly, significant decreases in the knee extensor strength deficit ratio (-18%) and percent contribution of vastus medialis to experimental torque (-24%) was observed pre- to post- hypertonic injection. No differences were observed with isotonic injections, confirming the validity of the model.INTERPRETATION: Our practical method to estimate strength ratios can be easily implemented within a musculoskeletal modeling framework to improve the validity of model estimates. This, in turn, can increase our understanding of the relationship between neuromuscular deficits and functional outcomes in patient populations.
U2 - 10.1016/j.clinbiomech.2019.04.005
DO - 10.1016/j.clinbiomech.2019.04.005
M3 - Journal article
C2 - 31071535
VL - 67
SP - 27
EP - 33
JO - Clinical Biomechanics
JF - Clinical Biomechanics
SN - 0268-0033
ER -
ID: 222622117