Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
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Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. / Mendham, Amy E.; Larsen, Steen; George, Cindy; Adams, Kevin; Hauksson, Jon; Olsson, Tommy; Fortuin-de Smidt, Melony C.; Nankam, Pamela A. Nono; Hakim, Olah; Goff, Louise M.; Pheiffer, Carmen; Goedecke, Julia H.
I: Scientific Reports, Bind 10, Nr. 1, 3785, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
AU - Mendham, Amy E.
AU - Larsen, Steen
AU - George, Cindy
AU - Adams, Kevin
AU - Hauksson, Jon
AU - Olsson, Tommy
AU - Fortuin-de Smidt, Melony C.
AU - Nankam, Pamela A. Nono
AU - Hakim, Olah
AU - Goff, Louise M.
AU - Pheiffer, Carmen
AU - Goedecke, Julia H.
PY - 2020
Y1 - 2020
N2 - We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (S-I). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p <0.05). Higher gSAT respiration was associated with higher gynoid fat (p <0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p <0.05). In response to training, S-I improved and gynoid fat decreased (p <0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p <0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p <0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.
AB - We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise training; and examined depot-specific associations with body fat distribution and insulin sensitivity (S-I). Obese, black South African women (n = 45) were randomized into exercise (n = 23) or control (n = 22) groups. Exercise group completed 12-weeks of aerobic and resistance training (n = 20), while the control group (n = 15) continued usual behaviours. Mitochondrial function (high-resolution respirometry and fluorometry) in gSAT and aSAT, SI (frequently sampled intravenous glucose tolerance test), body composition (dual-energy X-ray absorptiometry), and ectopic fat (MRI) were assessed pre- and post-intervention. At baseline, gSAT had higher mitochondrial respiratory capacity and hydrogen peroxide (H2O2) production than aSAT (p <0.05). Higher gSAT respiration was associated with higher gynoid fat (p <0.05). Higher gSAT H2O2 production and lower aSAT mitochondrial respiration were independently associated with lower SI (p <0.05). In response to training, S-I improved and gynoid fat decreased (p <0.05), while H2O2 production reduced in both depots, and mtDNA decreased in gSAT (p <0.05). Mitochondrial respiration increased in aSAT and correlated with a decrease in body fat and an increase in soleus and hepatic fat content (p <0.05). This study highlights the importance of understanding the differences in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin resistance and associated risk factors such as body fat distribution and ectopic lipid deposition. Furthermore, we highlight the benefits of exercise training in stimulating positive adaptations in mitochondrial function in gluteal and abdominal SAT depots.
KW - BODY-FAT DISTRIBUTION
KW - HIGH-RESOLUTION RESPIROMETRY
KW - INSULIN-RESISTANCE
KW - SKELETAL-MUSCLE
KW - INTENSITY
KW - WOMEN
KW - SENSITIVITY
KW - DYSFUNCTION
KW - HEALTH
KW - OXYGEN
U2 - 10.1038/s41598-020-60286-x
DO - 10.1038/s41598-020-60286-x
M3 - Journal article
C2 - 32123205
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 3785
ER -
ID: 248146064