Exercise intensity and markers of inflammation during and after (neo-) adjuvant cancer treatment
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Exercise intensity and markers of inflammation during and after (neo-) adjuvant cancer treatment. / Schauer, Tim; Mazzoni, Anne Sophie; Henriksson, Anna; Demmelmaier, Ingrid; Berntsen, Sveinung; Raastad, Truls; Nordin, Karin; Pedersen, Bente K.; Christensen, Jesper F.
I: Endocrine-Related Cancer, Bind 28, Nr. 3, 2021, s. 191-201.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exercise intensity and markers of inflammation during and after (neo-) adjuvant cancer treatment
AU - Schauer, Tim
AU - Mazzoni, Anne Sophie
AU - Henriksson, Anna
AU - Demmelmaier, Ingrid
AU - Berntsen, Sveinung
AU - Raastad, Truls
AU - Nordin, Karin
AU - Pedersen, Bente K.
AU - Christensen, Jesper F.
N1 - Publisher Copyright: © 2021 Society for Endocrinology
PY - 2021
Y1 - 2021
N2 - Exercise training has been hypothesized to lower the inflammatory burden for patients with cancer, but the role of exercise intensity is unknown. To this end, we compared the effects of high-intensity (HI) and low-to-moderate intensity (LMI) exercise on markers of inflammation in patients with curable breast, prostate and colorectal cancer undergoing primary adjuvant cancer treatment in a secondary analysis of the Phys-Can randomized trial (NCT02473003). Sub-group analyses focused on patients with breast cancer undergoing chemotherapy. Patients performed 6 months of combined aerobic and resistance exercise on either HI or LMI during and after primary adjuvant cancer treatment. Plasma taken at baseline, immediately post-treatment and post-intervention was analyzed for levels of interleukin 1 beta (IL1B), IL6, IL8, IL10, tumor-necrosis factor alpha (TNFA) and C-reactive protein (CRP). Intention-to-treat analyses of 394 participants revealed no significant between-group differences. Regardless of exercise intensity, significant increases of IL6, IL8, IL10 and TNFA post-treatment followed by significant declines, except for IL8, until post-intervention were observed with no difference for CRP or IL1B. Subgroup analyses of 154 patients with breast cancer undergoing chemotherapy revealed that CRP (estimated mean difference (95% CI): 0.59 (0.33; 1.06); P = 0.101) and TNFA (EMD (95% CI): 0.88 (0.77; 1); P = 0.053) increased less with HI exercise post-treatment compared to LMI. Exploratory cytokine co-regulation analysis revealed no difference between the groups. In patients with breast cancer undergoing chemotherapy, HI exercise resulted in a lesser increase of CRP and TNFA immediately post-treatment compared to LMI, potentially protecting against chemotherapy-related inflammation.
AB - Exercise training has been hypothesized to lower the inflammatory burden for patients with cancer, but the role of exercise intensity is unknown. To this end, we compared the effects of high-intensity (HI) and low-to-moderate intensity (LMI) exercise on markers of inflammation in patients with curable breast, prostate and colorectal cancer undergoing primary adjuvant cancer treatment in a secondary analysis of the Phys-Can randomized trial (NCT02473003). Sub-group analyses focused on patients with breast cancer undergoing chemotherapy. Patients performed 6 months of combined aerobic and resistance exercise on either HI or LMI during and after primary adjuvant cancer treatment. Plasma taken at baseline, immediately post-treatment and post-intervention was analyzed for levels of interleukin 1 beta (IL1B), IL6, IL8, IL10, tumor-necrosis factor alpha (TNFA) and C-reactive protein (CRP). Intention-to-treat analyses of 394 participants revealed no significant between-group differences. Regardless of exercise intensity, significant increases of IL6, IL8, IL10 and TNFA post-treatment followed by significant declines, except for IL8, until post-intervention were observed with no difference for CRP or IL1B. Subgroup analyses of 154 patients with breast cancer undergoing chemotherapy revealed that CRP (estimated mean difference (95% CI): 0.59 (0.33; 1.06); P = 0.101) and TNFA (EMD (95% CI): 0.88 (0.77; 1); P = 0.053) increased less with HI exercise post-treatment compared to LMI. Exploratory cytokine co-regulation analysis revealed no difference between the groups. In patients with breast cancer undergoing chemotherapy, HI exercise resulted in a lesser increase of CRP and TNFA immediately post-treatment compared to LMI, potentially protecting against chemotherapy-related inflammation.
KW - C-reactive protein
KW - Cancer
KW - Exercise
KW - Inflammation
KW - Tumor necrosis factor-alpha
U2 - 10.1530/ERC-20-0507
DO - 10.1530/ERC-20-0507
M3 - Journal article
C2 - 33608485
AN - SCOPUS:85103682822
VL - 28
SP - 191
EP - 201
JO - Endocrine - Related Cancer
JF - Endocrine - Related Cancer
SN - 1351-0088
IS - 3
ER -
ID: 301452938