TY - JOUR

T1 - European contribution to the study of ROS

T2 - A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

AU - Egea, Javier

AU - Fabregat, Isabel

AU - Frapart, Yves M

AU - Ghezzi, Pietro

AU - Görlach, Agnes

AU - Kietzmann, Thomas

AU - Kubaichuk, Kateryna

AU - Knaus, Ulla G

AU - Lopez, Manuela G

AU - Olaso-Gonzalez, Gloria

AU - Petry, Andreas

AU - Schulz, Rainer

AU - Viña, Jose

AU - Winyard, Paul G

AU - Abbas, Kahina

AU - Ademowo, Opeyemi S

AU - Afonso, Catarina B

AU - Andreadou, Ioanna

AU - Antelmann, Haike

AU - Antunes, Fernando

AU - Aslan, Mutay

AU - Bachschmid, Markus M

AU - Barbosa, Rui M

AU - Belousov, Vsevolod

AU - Berndt, Carsten

AU - Bernlohr, David

AU - Bertrán, Esther

AU - Bindoli, Alberto

AU - Bottari, Serge P

AU - Brito, Paula M

AU - Carrara, Guia

AU - Casas, Ana I

AU - Chatzi, Afroditi

AU - Chondrogianni, Niki

AU - Conrad, Marcus

AU - Cooke, Marcus S

AU - Costa, João G

AU - Cuadrado, Antonio

AU - My-Chan Dang, Pham

AU - De Smet, Barbara

AU - Debelec-Butuner, Bilge

AU - Dias, Irundika H K

AU - Dunn, Joe Dan

AU - Edson, Amanda J

AU - El Assar, Mariam

AU - El-Benna, Jamel

AU - Ferdinandy, Péter

AU - Fernandes, Ana S

AU - Fladmark, Kari E

AU - Förstermann, Ulrich

AU - Giniatullin, Rashid

AU - Giricz, Zoltán

AU - Görbe, Anikó

AU - Griffiths, Helen R

AU - Hampl, Vaclav

AU - Hanf, Alina

AU - Herget, Jan

AU - Hernansanz-Agustín, Pablo

AU - Hillion, Melanie

AU - Huang, Jingjing

AU - Ilikay, Serap

AU - Jansen-Dürr, Pidder

AU - Jaquet, Vincent

AU - Joles, Jaap A

AU - Kalyanaraman, Balaraman

AU - Kaminskyy, Danylo

AU - Karbaschi, Mahsa

AU - Kleanthous, Marina

AU - Klotz, Lars-Oliver

AU - Korac, Bato

AU - Korkmaz, Kemal Sami

AU - Koziel, Rafal

AU - Kračun, Damir

AU - Krause, Karl-Heinz

AU - Křen, Vladimír

AU - Krieg, Thomas

AU - Laranjinha, Joao

AU - Lazou, Antigone

AU - Li, Huige

AU - Martínez-Ruiz, Antonio

AU - Matsui, Reiko

AU - McBean, Gethin J

AU - Meredith, Stuart P

AU - Messens, Joris

AU - Miguel, Verónica

AU - Mikhed, Yuliya

AU - Milisav, Irina

AU - Milković, Lidija

AU - Miranda-Vizuete, Antonio

AU - Mojović, Miloš

AU - Monsalve, María

AU - Mouthuy, Pierre-Alexis

AU - Mulvey, John

AU - Münzel, Thomas

AU - Muzykantov, Vladimir

AU - Nguyen, Isabel T N

AU - Oelze, Matthias

AU - Oliveira, Nuno G

AU - Palmeira, Carlos M

AU - Papaevgeniou, Nikoletta

AU - Pavićević, Aleksandra

AU - Pedre, Brandán

AU - Peyrot, Fabienne

AU - Phylactides, Marios

AU - Pircalabioru, Gratiela G

AU - Pitt, Andrew R

AU - Poulsen, Henrik E

AU - Prieto, Ignacio

AU - Rigobello, Maria Pia

AU - Robledinos-Antón, Natalia

AU - Rodríguez-Mañas, Leocadio

AU - Rolo, Anabela P

AU - Rousset, Francis

AU - Ruskovska, Tatjana

AU - Saraiva, Nuno

AU - Sasson, Shlomo

AU - Schröder, Katrin

AU - Semen, Khrystyna

AU - Seredenina, Tamara

AU - Shakirzyanova, Anastasia

AU - Smith, Geoffrey L

AU - Soldati, Thierry

AU - Sousa, Bebiana C

AU - Spickett, Corinne M

AU - Stancic, Ana

AU - Stasia, Marie-José

AU - Steinbrenner, Holger

AU - Stepanić, Višnja

AU - Steven, Sebastian

AU - Tokatlidis, Kostas

AU - Tuncay, Erkan

AU - Turan, Belma

AU - Ursini, Fulvio

AU - Vacek, Jan

AU - Vajnerova, Olga

AU - Valentová, Kateřina

AU - Van Breusegem, Frank

AU - Varisli, Lokman

AU - Veal, Elizabeth A

AU - Yalçın, A Suha

AU - Yelisyeyeva, Olha

AU - Žarković, Neven

AU - Zatloukalová, Martina

AU - Zielonka, Jacek

AU - Touyz, Rhian M

AU - Papapetropoulos, Andreas

AU - Grune, Tilman

AU - Lamas, Santiago

AU - Schmidt, Harald H H W

AU - Di Lisa, Fabio

AU - Daiber, Andreas

N1 - Corrigendum: https://doi.org/10.1016/j.redox.2017.10.001

PY - 2017/10

Y1 - 2017/10

N2 - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

AB - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

KW - Journal Article

KW - Review

UR - https://www.sciencedirect.com/science/article/pii/S2213231717307474?via%3Dihub

U2 - 10.1016/j.redox.2017.05.007

DO - 10.1016/j.redox.2017.05.007

M3 - Review

C2 - 28577489

VL - 13

SP - 94

EP - 162

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

ER -