European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

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Standard

European all-cause excess and influenza-attributable mortality in the 2017/18 season : should the burden of influenza B be reconsidered? / Nielsen, J.; Vestergaard, L. S.; Richter, L.; Schmid, D.; Bustos, N.; Asikainen, T.; Trebbien, R.; Denissov, G.; Innos, K.; Virtanen, M. J.; Fouillet, A.; Lytras, T.; Gkolfinopoulou, K.; Heiden, M. an der; Grabenhenrich, L.; Uphoff, H.; Paldy, A.; Bobvos, J.; Domegan, L.; O'Donnell, J.; Scortichini, M.; de Martino, A.; Mossong, J.; England, K.; Melillo, J.; van Asten, L.; de Lange, M. MA; Tønnessen, R.; White, R. A.; da Silva, S. P.; Rodrigues, A. P.; Larrauri, A.; Mazagatos, C.; Farah, A.; Carnahan, A. D.; Junker, C.; Sinnathamby, M.; Pebody, R. G.; Andrews, N.; Reynolds, A.; McMenamin, J.; Brown, C. S.; Adlhoch, C.; Penttinen, P.; Mølbak, K.; Krause, T. G.

I: Clinical Microbiology and Infection, Bind 25, Nr. 10, 2019, s. 1266-1276.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, J, Vestergaard, LS, Richter, L, Schmid, D, Bustos, N, Asikainen, T, Trebbien, R, Denissov, G, Innos, K, Virtanen, MJ, Fouillet, A, Lytras, T, Gkolfinopoulou, K, Heiden, MAD, Grabenhenrich, L, Uphoff, H, Paldy, A, Bobvos, J, Domegan, L, O'Donnell, J, Scortichini, M, de Martino, A, Mossong, J, England, K, Melillo, J, van Asten, L, de Lange, MMA, Tønnessen, R, White, RA, da Silva, SP, Rodrigues, AP, Larrauri, A, Mazagatos, C, Farah, A, Carnahan, AD, Junker, C, Sinnathamby, M, Pebody, RG, Andrews, N, Reynolds, A, McMenamin, J, Brown, CS, Adlhoch, C, Penttinen, P, Mølbak, K & Krause, TG 2019, 'European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?', Clinical Microbiology and Infection, bind 25, nr. 10, s. 1266-1276. https://doi.org/10.1016/j.cmi.2019.02.011

APA

Nielsen, J., Vestergaard, L. S., Richter, L., Schmid, D., Bustos, N., Asikainen, T., Trebbien, R., Denissov, G., Innos, K., Virtanen, M. J., Fouillet, A., Lytras, T., Gkolfinopoulou, K., Heiden, M. A. D., Grabenhenrich, L., Uphoff, H., Paldy, A., Bobvos, J., Domegan, L., ... Krause, T. G. (2019). European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? Clinical Microbiology and Infection, 25(10), 1266-1276. https://doi.org/10.1016/j.cmi.2019.02.011

Vancouver

Nielsen J, Vestergaard LS, Richter L, Schmid D, Bustos N, Asikainen T o.a. European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? Clinical Microbiology and Infection. 2019;25(10):1266-1276. https://doi.org/10.1016/j.cmi.2019.02.011

Author

Nielsen, J. ; Vestergaard, L. S. ; Richter, L. ; Schmid, D. ; Bustos, N. ; Asikainen, T. ; Trebbien, R. ; Denissov, G. ; Innos, K. ; Virtanen, M. J. ; Fouillet, A. ; Lytras, T. ; Gkolfinopoulou, K. ; Heiden, M. an der ; Grabenhenrich, L. ; Uphoff, H. ; Paldy, A. ; Bobvos, J. ; Domegan, L. ; O'Donnell, J. ; Scortichini, M. ; de Martino, A. ; Mossong, J. ; England, K. ; Melillo, J. ; van Asten, L. ; de Lange, M. MA ; Tønnessen, R. ; White, R. A. ; da Silva, S. P. ; Rodrigues, A. P. ; Larrauri, A. ; Mazagatos, C. ; Farah, A. ; Carnahan, A. D. ; Junker, C. ; Sinnathamby, M. ; Pebody, R. G. ; Andrews, N. ; Reynolds, A. ; McMenamin, J. ; Brown, C. S. ; Adlhoch, C. ; Penttinen, P. ; Mølbak, K. ; Krause, T. G. / European all-cause excess and influenza-attributable mortality in the 2017/18 season : should the burden of influenza B be reconsidered?. I: Clinical Microbiology and Infection. 2019 ; Bind 25, Nr. 10. s. 1266-1276.

Bibtex

@article{af38aebd3f664477adf20095d01d0876,
title = "European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?",
abstract = "Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.",
keywords = "B/Yamagata, EuroMOMO, FluMOMO, Influenza, Mortality",
author = "J. Nielsen and Vestergaard, {L. S.} and L. Richter and D. Schmid and N. Bustos and T. Asikainen and R. Trebbien and G. Denissov and K. Innos and Virtanen, {M. J.} and A. Fouillet and T. Lytras and K. Gkolfinopoulou and Heiden, {M. an der} and L. Grabenhenrich and H. Uphoff and A. Paldy and J. Bobvos and L. Domegan and J. O'Donnell and M. Scortichini and {de Martino}, A. and J. Mossong and K. England and J. Melillo and {van Asten}, L. and {de Lange}, {M. MA} and R. T{\o}nnessen and White, {R. A.} and {da Silva}, {S. P.} and Rodrigues, {A. P.} and A. Larrauri and C. Mazagatos and A. Farah and Carnahan, {A. D.} and C. Junker and M. Sinnathamby and Pebody, {R. G.} and N. Andrews and A. Reynolds and J. McMenamin and Brown, {C. S.} and C. Adlhoch and P. Penttinen and K. M{\o}lbak and Krause, {T. G.}",
year = "2019",
doi = "10.1016/j.cmi.2019.02.011",
language = "English",
volume = "25",
pages = "1266--1276",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - European all-cause excess and influenza-attributable mortality in the 2017/18 season

T2 - should the burden of influenza B be reconsidered?

AU - Nielsen, J.

AU - Vestergaard, L. S.

AU - Richter, L.

AU - Schmid, D.

AU - Bustos, N.

AU - Asikainen, T.

AU - Trebbien, R.

AU - Denissov, G.

AU - Innos, K.

AU - Virtanen, M. J.

AU - Fouillet, A.

AU - Lytras, T.

AU - Gkolfinopoulou, K.

AU - Heiden, M. an der

AU - Grabenhenrich, L.

AU - Uphoff, H.

AU - Paldy, A.

AU - Bobvos, J.

AU - Domegan, L.

AU - O'Donnell, J.

AU - Scortichini, M.

AU - de Martino, A.

AU - Mossong, J.

AU - England, K.

AU - Melillo, J.

AU - van Asten, L.

AU - de Lange, M. MA

AU - Tønnessen, R.

AU - White, R. A.

AU - da Silva, S. P.

AU - Rodrigues, A. P.

AU - Larrauri, A.

AU - Mazagatos, C.

AU - Farah, A.

AU - Carnahan, A. D.

AU - Junker, C.

AU - Sinnathamby, M.

AU - Pebody, R. G.

AU - Andrews, N.

AU - Reynolds, A.

AU - McMenamin, J.

AU - Brown, C. S.

AU - Adlhoch, C.

AU - Penttinen, P.

AU - Mølbak, K.

AU - Krause, T. G.

PY - 2019

Y1 - 2019

N2 - Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.

AB - Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.

KW - B/Yamagata

KW - EuroMOMO

KW - FluMOMO

KW - Influenza

KW - Mortality

U2 - 10.1016/j.cmi.2019.02.011

DO - 10.1016/j.cmi.2019.02.011

M3 - Journal article

C2 - 30790685

AN - SCOPUS:85063662041

VL - 25

SP - 1266

EP - 1276

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 10

ER -

ID: 241097570