European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?
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European all-cause excess and influenza-attributable mortality in the 2017/18 season : should the burden of influenza B be reconsidered? / Nielsen, J.; Vestergaard, L. S.; Richter, L.; Schmid, D.; Bustos, N.; Asikainen, T.; Trebbien, R.; Denissov, G.; Innos, K.; Virtanen, M. J.; Fouillet, A.; Lytras, T.; Gkolfinopoulou, K.; Heiden, M. an der; Grabenhenrich, L.; Uphoff, H.; Paldy, A.; Bobvos, J.; Domegan, L.; O'Donnell, J.; Scortichini, M.; de Martino, A.; Mossong, J.; England, K.; Melillo, J.; van Asten, L.; de Lange, M. MA; Tønnessen, R.; White, R. A.; da Silva, S. P.; Rodrigues, A. P.; Larrauri, A.; Mazagatos, C.; Farah, A.; Carnahan, A. D.; Junker, C.; Sinnathamby, M.; Pebody, R. G.; Andrews, N.; Reynolds, A.; McMenamin, J.; Brown, C. S.; Adlhoch, C.; Penttinen, P.; Mølbak, K.; Krause, T. G.
I: Clinical Microbiology and Infection, Bind 25, Nr. 10, 2019, s. 1266-1276.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - European all-cause excess and influenza-attributable mortality in the 2017/18 season
T2 - should the burden of influenza B be reconsidered?
AU - Nielsen, J.
AU - Vestergaard, L. S.
AU - Richter, L.
AU - Schmid, D.
AU - Bustos, N.
AU - Asikainen, T.
AU - Trebbien, R.
AU - Denissov, G.
AU - Innos, K.
AU - Virtanen, M. J.
AU - Fouillet, A.
AU - Lytras, T.
AU - Gkolfinopoulou, K.
AU - Heiden, M. an der
AU - Grabenhenrich, L.
AU - Uphoff, H.
AU - Paldy, A.
AU - Bobvos, J.
AU - Domegan, L.
AU - O'Donnell, J.
AU - Scortichini, M.
AU - de Martino, A.
AU - Mossong, J.
AU - England, K.
AU - Melillo, J.
AU - van Asten, L.
AU - de Lange, M. MA
AU - Tønnessen, R.
AU - White, R. A.
AU - da Silva, S. P.
AU - Rodrigues, A. P.
AU - Larrauri, A.
AU - Mazagatos, C.
AU - Farah, A.
AU - Carnahan, A. D.
AU - Junker, C.
AU - Sinnathamby, M.
AU - Pebody, R. G.
AU - Andrews, N.
AU - Reynolds, A.
AU - McMenamin, J.
AU - Brown, C. S.
AU - Adlhoch, C.
AU - Penttinen, P.
AU - Mølbak, K.
AU - Krause, T. G.
PY - 2019
Y1 - 2019
N2 - Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
AB - Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.
KW - B/Yamagata
KW - EuroMOMO
KW - FluMOMO
KW - Influenza
KW - Mortality
U2 - 10.1016/j.cmi.2019.02.011
DO - 10.1016/j.cmi.2019.02.011
M3 - Journal article
C2 - 30790685
AN - SCOPUS:85063662041
VL - 25
SP - 1266
EP - 1276
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
IS - 10
ER -
ID: 241097570