Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography. / Henriksen, Otto Mølby; Larsson, Henrik B W; Hansen, Adam E; Grüner, Julie Marie; Law, Ian; Rostrup, Egill.
I: Journal of Magnetic Resonance Imaging, Bind 35, Nr. 6, 2012, s. 1290-1299.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography
AU - Henriksen, Otto Mølby
AU - Larsson, Henrik B W
AU - Hansen, Adam E
AU - Grüner, Julie Marie
AU - Law, Ian
AU - Rostrup, Egill
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2012
Y1 - 2012
N2 - PURPOSE: To investigate the within and between subject variability of quantitative cerebral blood flow (CBF) measurements in normal subjects using various MRI techniques and positron emission tomography (PET). MATERIALS AND METHODS: Repeated CBF measurements were performed in 17 healthy, young subjects using three different MRI techniques: arterial spin labeling (ASL), dynamic contrast enhanced T1 weighted perfusion MRI (DCE) and phase contrast mapping (PCM). All MRI measurements were performed within the same session. In 10 of the subjects repeated CBF measurements by (15) O labeled water PET had recently been performed. A mixed linear model was used to estimate between subject (CV(betw) ) and within subject (CV(with) ) coefficients of variation. RESULTS: Mean global CBF, CV(betw) and CV(with) using each of the four methods were for PCM 65.2 mL/100 g/min, 17.4% and 7.4%, for ASL 37.1 mL/100 g/min, 16.2% and 4.8%, for DCE 43.0 mL/100 g/min, 20.0%, 15.1% and for PET 41.9 mL/100 g/min, 16.5% and 11.9%, respectively. Only for DCE and PCM a significant positive correlation between measurements was demonstrated. CONCLUSION: These findings confirm large between subject variability in CBF measurements, but suggest also that in healthy subjects a subject-method interaction is a possible source of between subject variability and of method differences. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc.
AB - PURPOSE: To investigate the within and between subject variability of quantitative cerebral blood flow (CBF) measurements in normal subjects using various MRI techniques and positron emission tomography (PET). MATERIALS AND METHODS: Repeated CBF measurements were performed in 17 healthy, young subjects using three different MRI techniques: arterial spin labeling (ASL), dynamic contrast enhanced T1 weighted perfusion MRI (DCE) and phase contrast mapping (PCM). All MRI measurements were performed within the same session. In 10 of the subjects repeated CBF measurements by (15) O labeled water PET had recently been performed. A mixed linear model was used to estimate between subject (CV(betw) ) and within subject (CV(with) ) coefficients of variation. RESULTS: Mean global CBF, CV(betw) and CV(with) using each of the four methods were for PCM 65.2 mL/100 g/min, 17.4% and 7.4%, for ASL 37.1 mL/100 g/min, 16.2% and 4.8%, for DCE 43.0 mL/100 g/min, 20.0%, 15.1% and for PET 41.9 mL/100 g/min, 16.5% and 11.9%, respectively. Only for DCE and PCM a significant positive correlation between measurements was demonstrated. CONCLUSION: These findings confirm large between subject variability in CBF measurements, but suggest also that in healthy subjects a subject-method interaction is a possible source of between subject variability and of method differences. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc.
U2 - 10.1002/jmri.23579
DO - 10.1002/jmri.23579
M3 - Journal article
C2 - 22246715
VL - 35
SP - 1290
EP - 1299
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 6
ER -
ID: 40158352