Estimating drop-out probabilities of STR alleles accounting for stutters, detection threshold truncation and degradation
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Estimating drop-out probabilities of STR alleles accounting for stutters, detection threshold truncation and degradation. / Tvedebrink, Torben; Asplund, Maria; Eriksen, Poul Svante; Mogensen, Helle Smidt; Morling, Niels.
I: Forensic Science International: Genetics Supplement Series, Bind 4, Nr. 1, 2013, s. e51-e52.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Estimating drop-out probabilities of STR alleles accounting for stutters, detection threshold truncation and degradation
AU - Tvedebrink, Torben
AU - Asplund, Maria
AU - Eriksen, Poul Svante
AU - Mogensen, Helle Smidt
AU - Morling, Niels
N1 - Funding Information: This work was in part funded by Aalborg University and University of Copenhagen .
PY - 2013
Y1 - 2013
N2 - Allelic drop-out continues to be a challenge to forensic geneticists when interpreting crime scene evidence and calculating the evidential weight. Methods exist for estimating the probability of allelic drop-out, where the most promising methods use the signal intensities as input for quantifying the drop-out probability. Using data from real crime cases, we demonstrate that taking degradation of the biological material and truncation of the data due to a detection threshold into account is superior to previous approaches. An additional correction for stuttering effects showed limited improvement.
AB - Allelic drop-out continues to be a challenge to forensic geneticists when interpreting crime scene evidence and calculating the evidential weight. Methods exist for estimating the probability of allelic drop-out, where the most promising methods use the signal intensities as input for quantifying the drop-out probability. Using data from real crime cases, we demonstrate that taking degradation of the biological material and truncation of the data due to a detection threshold into account is superior to previous approaches. An additional correction for stuttering effects showed limited improvement.
KW - Allelic drop-out
KW - Degradation
KW - Forensic genetics
KW - Stutter correction
KW - Truncation
UR - http://www.scopus.com/inward/record.url?scp=84889883157&partnerID=8YFLogxK
U2 - 10.1016/j.fsigss.2013.10.026
DO - 10.1016/j.fsigss.2013.10.026
M3 - Journal article
AN - SCOPUS:84889883157
VL - 4
SP - e51-e52
JO - Forensic Science International: Genetics. Supplement Series
JF - Forensic Science International: Genetics. Supplement Series
SN - 1875-1768
IS - 1
ER -
ID: 301362879