Epstein-barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland
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Epstein-barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland. / Friborg, Jeppe; Jarrett, Ruth F.; Liu, Mei Ying; Falk, Kerstin I.; Koch, Anders; Olsen, Ove R.; Duncan, Pamela; Wohlfarht, Jan; Chen, Jen Yang; Melbye, Mads.
I: Journal of Medical Virology, Bind 79, Nr. 12, 12.2007, s. 1877-1881.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Epstein-barr virus immune response in high-risk nasopharyngeal carcinoma families in Greenland
AU - Friborg, Jeppe
AU - Jarrett, Ruth F.
AU - Liu, Mei Ying
AU - Falk, Kerstin I.
AU - Koch, Anders
AU - Olsen, Ove R.
AU - Duncan, Pamela
AU - Wohlfarht, Jan
AU - Chen, Jen Yang
AU - Melbye, Mads
PY - 2007/12
Y1 - 2007/12
N2 - Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N = 20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P < 0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits.
AB - Undifferentiated nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV) infection. Presence of EBV IgA antibodies is rare among healthy individuals and is used as a marker of nasopharyngeal carcinoma in high-incidence populations. Reasons for EBV IgA seropositivity are unknown, but high EBV IgA levels have been found among unaffected close family members and spouses to nasopharyngeal carcinoma patients in Chinese populations. In Greenland, a nasopharyngeal carcinoma-high-incidence area, we compared EBV serology and viral load in high-risk nasopharyngeal carcinoma family members (N = 20) and controls without nasopharyngeal carcinoma-affected relatives (N = 90). There was no significant difference in EBV viral loads between relatives and controls, and EBV was detected in plasma in 5.0% of relatives and 11.4% of controls. There was no significant difference in EBV serology, but the seroprevalence of EBV viral capsid antigen (VCA) IgA was high in both relatives (25.0%) and controls (20.5%). Compared with anti-VCA IgA-negative, anti-VCA IgA-positive individuals had significantly higher EBV viral loads in peripheral blood mononuclear cells (PBMCs) (P < 0.01). The very high prevalence of anti-VCA IgA indicates that this antibody is unsuitable for nasopharyngeal carcinoma screening among Inuits.
KW - Epstein-Barr virus
KW - Immunology
KW - Inuit
KW - Nasopharyngeal carcinoma
UR - http://www.scopus.com/inward/record.url?scp=35548982078&partnerID=8YFLogxK
U2 - 10.1002/jmv.21014
DO - 10.1002/jmv.21014
M3 - Journal article
C2 - 17935169
AN - SCOPUS:35548982078
VL - 79
SP - 1877
EP - 1881
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 12
ER -
ID: 247936130