Epigenetic Memories: The Hidden Drivers of Bacterial Persistence?
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Epigenetic Memories : The Hidden Drivers of Bacterial Persistence? / Riber, Leise; Hansen, Lars Hestbjerg.
I: Trends in Microbiology, Bind 29, Nr. 3, 2021, s. 190-194.Publikation: Bidrag til tidsskrift › Leder › Forskning
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TY - JOUR
T1 - Epigenetic Memories
T2 - The Hidden Drivers of Bacterial Persistence?
AU - Riber, Leise
AU - Hansen, Lars Hestbjerg
PY - 2021
Y1 - 2021
N2 - Epigenetic modifications, including DNA methylation, stably alter gene expression without modifying genomic sequences. Recent evidence suggests that epigenetic regulation coupled with a long-term 'memory' effect plays a major role within bacterial persistence formation. Today, emerging high-resolution, single-molecule sequencing technologies allow an increased focus on DNA modifications as regulatory epigenetic marks, which presents a unique opportunity to identify possible epigenetic drivers of bacterial persistence.
AB - Epigenetic modifications, including DNA methylation, stably alter gene expression without modifying genomic sequences. Recent evidence suggests that epigenetic regulation coupled with a long-term 'memory' effect plays a major role within bacterial persistence formation. Today, emerging high-resolution, single-molecule sequencing technologies allow an increased focus on DNA modifications as regulatory epigenetic marks, which presents a unique opportunity to identify possible epigenetic drivers of bacterial persistence.
KW - bacterial persistence
KW - DNA methylation
KW - epigenetic inheritance
KW - gene expression regulation
KW - nanopore sequencing
KW - SMRT sequencing
U2 - 10.1016/j.tim.2020.12.005
DO - 10.1016/j.tim.2020.12.005
M3 - Editorial
C2 - 33414017
AN - SCOPUS:85098791519
VL - 29
SP - 190
EP - 194
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 3
ER -
ID: 258399706