Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults

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Standard

Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults. / Lee, Dong-Wook; Oh, Seung-Ha; Park, Moo-Kyun; Lim, Youn-Hee; Hong, Yun-Chul.

I: Occupational and Environmental Medicine, Bind 75, Nr. 7, 2018, s. 515-521.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, D-W, Oh, S-H, Park, M-K, Lim, Y-H & Hong, Y-C 2018, 'Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults', Occupational and Environmental Medicine, bind 75, nr. 7, s. 515-521. https://doi.org/10.1136/oemed-2017-104631

APA

Lee, D-W., Oh, S-H., Park, M-K., Lim, Y-H., & Hong, Y-C. (2018). Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults. Occupational and Environmental Medicine, 75(7), 515-521. https://doi.org/10.1136/oemed-2017-104631

Vancouver

Lee D-W, Oh S-H, Park M-K, Lim Y-H, Hong Y-C. Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults. Occupational and Environmental Medicine. 2018;75(7):515-521. https://doi.org/10.1136/oemed-2017-104631

Author

Lee, Dong-Wook ; Oh, Seung-Ha ; Park, Moo-Kyun ; Lim, Youn-Hee ; Hong, Yun-Chul. / Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults. I: Occupational and Environmental Medicine. 2018 ; Bind 75, Nr. 7. s. 515-521.

Bibtex

@article{eb1770bcfbb64cfa9ce79c370ad082bf,

title = "Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults",

abstract = "OBJECTIVES: Chronic otitis media (COM) is caused by an infection of the middle ear, although it may also be associated with environmental pollutants. Recent reports found that cadmium exposure could be toxic to middle ear cell lines, but the role of cadmium in the development of COM in humans has not been examined to date. We hypothesised that environmental cadmium exposure was associated with an increased risk of COM in the general population.METHODS: We analysed cross-sectional data for 5331 adults of 20 years of age or above, obtained from the Korea National Health and Nutrition Examination Survey 2010-2012. We examined the association between blood cadmium levels and COM diagnosed by an otolaryngologist.RESULTS: The highest quartile group of cadmium blood concentration was associated with an OR of 3.33 (95% CI 1.78 to 7.53) for COM, after adjusting for potential confounding factors. Doubling blood cadmium concentration resulted in an OR of 1.58 (95% CI 1.19 to 2.08) for COM. These associations were robust on sensitivity analyses after excluding current smokers and former smokers and after excluding subjects with a potential history of occupational exposure to cadmium.CONCLUSIONS: The results of our study suggest that environmental cadmium exposure is associated with increased risk of COM, and further studies are warranted to understand the pathogenetic mechanism by which COM is caused by cadmium exposure.",

keywords = "Adult, Aged, Cadmium/adverse effects, Chronic Disease, Cross-Sectional Studies, Environmental Exposure/adverse effects, Environmental Pollutants/adverse effects, Female, Health Surveys, Humans, Male, Middle Aged, Otitis Media/blood, Republic of Korea, Risk Factors, Young Adult",

author = "Dong-Wook Lee and Seung-Ha Oh and Moo-Kyun Park and Youn-Hee Lim and Yun-Chul Hong",

note = "{\textcopyright} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",

year = "2018",

doi = "10.1136/oemed-2017-104631",

language = "English",

volume = "75",

pages = "515--521",

journal = "Occupational and Environmental Medicine",

issn = "1351-0711",

publisher = "B M J Group",

number = "7",

}

RIS

TY - JOUR

T1 - Environmental cadmium exposure is associated with elevated risk of chronic otitis media in adults

AU - Lee, Dong-Wook

AU - Oh, Seung-Ha

AU - Park, Moo-Kyun

AU - Lim, Youn-Hee

AU - Hong, Yun-Chul

PY - 2018

Y1 - 2018

N2 - OBJECTIVES: Chronic otitis media (COM) is caused by an infection of the middle ear, although it may also be associated with environmental pollutants. Recent reports found that cadmium exposure could be toxic to middle ear cell lines, but the role of cadmium in the development of COM in humans has not been examined to date. We hypothesised that environmental cadmium exposure was associated with an increased risk of COM in the general population.METHODS: We analysed cross-sectional data for 5331 adults of 20 years of age or above, obtained from the Korea National Health and Nutrition Examination Survey 2010-2012. We examined the association between blood cadmium levels and COM diagnosed by an otolaryngologist.RESULTS: The highest quartile group of cadmium blood concentration was associated with an OR of 3.33 (95% CI 1.78 to 7.53) for COM, after adjusting for potential confounding factors. Doubling blood cadmium concentration resulted in an OR of 1.58 (95% CI 1.19 to 2.08) for COM. These associations were robust on sensitivity analyses after excluding current smokers and former smokers and after excluding subjects with a potential history of occupational exposure to cadmium.CONCLUSIONS: The results of our study suggest that environmental cadmium exposure is associated with increased risk of COM, and further studies are warranted to understand the pathogenetic mechanism by which COM is caused by cadmium exposure.

AB - OBJECTIVES: Chronic otitis media (COM) is caused by an infection of the middle ear, although it may also be associated with environmental pollutants. Recent reports found that cadmium exposure could be toxic to middle ear cell lines, but the role of cadmium in the development of COM in humans has not been examined to date. We hypothesised that environmental cadmium exposure was associated with an increased risk of COM in the general population.METHODS: We analysed cross-sectional data for 5331 adults of 20 years of age or above, obtained from the Korea National Health and Nutrition Examination Survey 2010-2012. We examined the association between blood cadmium levels and COM diagnosed by an otolaryngologist.RESULTS: The highest quartile group of cadmium blood concentration was associated with an OR of 3.33 (95% CI 1.78 to 7.53) for COM, after adjusting for potential confounding factors. Doubling blood cadmium concentration resulted in an OR of 1.58 (95% CI 1.19 to 2.08) for COM. These associations were robust on sensitivity analyses after excluding current smokers and former smokers and after excluding subjects with a potential history of occupational exposure to cadmium.CONCLUSIONS: The results of our study suggest that environmental cadmium exposure is associated with increased risk of COM, and further studies are warranted to understand the pathogenetic mechanism by which COM is caused by cadmium exposure.

KW - Adult

KW - Aged

KW - Cadmium/adverse effects

KW - Chronic Disease

KW - Cross-Sectional Studies

KW - Environmental Exposure/adverse effects

KW - Environmental Pollutants/adverse effects

KW - Female

KW - Health Surveys

KW - Humans

KW - Male

KW - Middle Aged

KW - Otitis Media/blood

KW - Republic of Korea

KW - Risk Factors

KW - Young Adult

U2 - 10.1136/oemed-2017-104631

DO - 10.1136/oemed-2017-104631

M3 - Journal article

C2 - 29581150

VL - 75

SP - 515

EP - 521

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 7

ER -

ID: 230068086